1990
Gilles de La Tourette's syndrome and some forms of obsessive-compulsive disorder may share a common genetic diathesis.
Leckman JF, Chittenden EH. Gilles de La Tourette's syndrome and some forms of obsessive-compulsive disorder may share a common genetic diathesis. L Encéphale 1990, 16 Spec No: 321-3. PMID: 2209489.Peer-Reviewed Original ResearchConceptsPathophysiology of TSGilles de la Tourette's syndromeObsessive-compulsive disorderLa Tourette's syndromeTourette syndromeOCD patientsCerebrospinal fluid studiesRecent neuropathological studiesEndogenous opioid peptidesMesocortical dopaminergic systemCases of OCDCSF dynorphinNeuropathological studiesCommon genetic diathesisRaphe nucleusBasal gangliaSerotoninergic systemSerotonergic systemClinical studiesDopaminergic systemCommon neural substrateTS patientsNeuropharmacological studiesOpioid peptidesNormal controls
1988
Elevated CSF dynorphin A [1–8] in Tourette's syndrome
Leckman JF, Riddle MA, Berrettini WH, Anderson GM, Hardin M, Chappell P, Bissette G, Nemeroff CB, Goodman WK, Cohen DJ. Elevated CSF dynorphin A [1–8] in Tourette's syndrome. Life Sciences 1988, 43: 2015-2023. PMID: 2463450, DOI: 10.1016/0024-3205(88)90575-9.Peer-Reviewed Original ResearchConceptsPathobiology of TSTourette syndromeNeuroanatomic distributionEndogenous opioidsNeuropathological studiesObsessive-compulsive disorderPrevalence of TSBehavioral effectsPost-mortem brain studiesPathophysiology of TSGilles de la Tourette's syndromeCentral dopaminergic neuronsRecent neuropathological studiesLevels of dynorphinSevere Tourette syndromeBasal ganglia structuresChronic neuropsychiatric disorderLa Tourette's syndromeCentral monoaminergicCSF dynorphinElevated CSFStriatal fibersCSF studiesDopaminergic neuronsBasal ganglia