2018
Efficacy and Safety of Deep Brain Stimulation in Tourette Syndrome: The International Tourette Syndrome Deep Brain Stimulation Public Database and Registry
Martinez-Ramirez D, Jimenez-Shahed J, Leckman JF, Porta M, Servello D, Meng FG, Kuhn J, Huys D, Baldermann JC, Foltynie T, Hariz MI, Joyce EM, Zrinzo L, Kefalopoulou Z, Silburn P, Coyne T, Mogilner AY, Pourfar MH, Khandhar SM, Auyeung M, Ostrem JL, Visser-Vandewalle V, Welter ML, Mallet L, Karachi C, Houeto JL, Klassen BT, Ackermans L, Kaido T, Temel Y, Gross RE, Walker HC, Lozano AM, Walter BL, Mari Z, Anderson WS, Changizi BK, Moro E, Zauber SE, Schrock LE, Zhang JG, Hu W, Rizer K, Monari EH, Foote KD, Malaty IA, Deeb W, Gunduz A, Okun MS. Efficacy and Safety of Deep Brain Stimulation in Tourette Syndrome: The International Tourette Syndrome Deep Brain Stimulation Public Database and Registry. JAMA Neurology 2018, 75: 353-359. PMID: 29340590, PMCID: PMC5885852, DOI: 10.1001/jamaneurol.2017.4317.Peer-Reviewed Original ResearchConceptsDeep brain stimulationGlobus pallidus internusTourette syndromeDBS implantationBrain stimulationAdverse eventsOutcome of DBSSafety of DBSYale Global Tic Severity Scale (YGTSS) scoresPosterior globus pallidus internusOverall adverse event rateYale Global Tic Severity ScaleStimulation-induced adverse effectsMedically refractory symptomsImportant adverse eventsAdverse event ratesRefractory Tourette syndromeSeverity Scale scoreTic Severity ScaleSelf-injurious behaviorRefractory symptomsSymptomatic improvementIntracranial hemorrhageObsessive-compulsive disorderInternal capsule
2016
The International Deep Brain Stimulation Registry and Database for Gilles de la Tourette Syndrome: How Does It Work?
Deeb W, Rossi PJ, Porta M, Visser-Vandewalle V, Servello D, Silburn P, Coyne T, Leckman JF, Foltynie T, Hariz M, Joyce EM, Zrinzo L, Kefalopoulou Z, Welter ML, Karachi C, Mallet L, Houeto JL, Shahed-Jimenez J, Meng FG, Klassen BT, Mogilner AY, Pourfar MH, Kuhn J, Ackermans L, Kaido T, Temel Y, Gross RE, Walker HC, Lozano AM, Khandhar SM, Walter BL, Walter E, Mari Z, Changizi BK, Moro E, Baldermann JC, Huys D, Zauber SE, Schrock LE, Zhang JG, Hu W, Foote KD, Rizer K, Mink JW, Woods DW, Gunduz A, Okun MS. The International Deep Brain Stimulation Registry and Database for Gilles de la Tourette Syndrome: How Does It Work? Frontiers In Neuroscience 2016, 10: 170. PMID: 27199634, PMCID: PMC4842757, DOI: 10.3389/fnins.2016.00170.Peer-Reviewed Original ResearchDeep brain stimulationTourette syndromeDBS centersSmall case seriesCombination of motorTourette AssociationCase seriesCase reportInternational registryBrain targetsMovement disordersVocal ticsRegulatory agency approvalParkinson's diseaseSevere casesBrain stimulationNeuropsychiatric diseasesRegistryBehavioral therapyGilles deT patientsDBS casesOverall small numberDiseaseAgency approvalOn the Nature of Separation Challenges and Attachment Solutions in Severe, Refractory Gilles de la Tourette Syndrome (GTS): Deep Brain Stimulation (DBS) Has Been Helpful, But What About Rikki and Luci and Now Riley?
Leckman J. On the Nature of Separation Challenges and Attachment Solutions in Severe, Refractory Gilles de la Tourette Syndrome (GTS): Deep Brain Stimulation (DBS) Has Been Helpful, But What About Rikki and Luci and Now Riley? 2016, 67-73. DOI: 10.1007/978-3-319-42190-2_12.Peer-Reviewed Original Research
2014
Tourette syndrome deep brain stimulation: A review and updated recommendations
Schrock LE, Mink JW, Woods DW, Porta M, Servello D, Visser‐Vandewalle V, Silburn PA, Foltynie T, Walker HC, Shahed‐Jimenez J, Savica R, Klassen BT, Machado AG, Foote KD, Zhang J, Hu W, Ackermans L, Temel Y, Mari Z, Changizi BK, Lozano A, Auyeung M, Kaido T, Agid Y, Welter ML, Khandhar SM, Mogilner AY, Pourfar MH, Walter BL, Juncos JL, Gross RE, Kuhn J, Leckman JF, Neimat JA, Okun MS, Group T. Tourette syndrome deep brain stimulation: A review and updated recommendations. Movement Disorders 2014, 30: 448-471. PMID: 25476818, DOI: 10.1002/mds.26094.Peer-Reviewed Original ResearchConceptsDeep brain stimulationTourette syndromeBrain stimulationBehavioral treatment trialsFifth Edition diagnosisPostoperative outcome measuresOptimal surgical approachMultidisciplinary team approachTourette syndrome patientsMultiple brain targetsYears of ageLocal ethics committeeInstitutional review boardDBS centersMedication refractoryUrgent indicationsSevere motorSurgical approachTreatment trialsBrain targetsEdition diagnosisVocal ticsSyndrome patientsOutcome measuresHigh risk
2013
Lessons Learned from Open-label Deep Brain Stimulation for Tourette Syndrome: Eight Cases over 7 Years
Motlagh MG, Smith ME, Landeros-Weisenberger A, Kobets AJ, King RA, Miravite J, de Lotbinière AC, Alterman RL, Mogilner AY, Pourfar MH, Okun MS, Leckman JF. Lessons Learned from Open-label Deep Brain Stimulation for Tourette Syndrome: Eight Cases over 7 Years. Tremor And Other Hyperkinetic Movements 2013, 3: 03. PMID: 24255802, PMCID: PMC3822402, DOI: 10.5334/tohm.126.Peer-Reviewed Original ResearchDeep brain stimulationYale Global Tic Severity ScaleTourette syndromeBrain targetsBrain stimulationMedication-refractory Tourette syndromeHomogenous clinical entityOpen-label experienceRefractory Gilles deSerious adverse eventsSelection of patientsRisk of surgeryMidline thalamic nucleiTic Severity ScalePatient-specific outcomesAdverse eventsClinical improvementPostoperative improvementClinical entityGlobus pallidusDBS patientsThalamic nucleiInclusion criteriaSeverity ScaleClinical experience
2007
Deep brain stimulation in Tourette's syndrome
Bajwa RJ, de Lotbinière AJ, King RA, Jabbari B, Quatrano S, Kunze K, Scahill L, Leckman JF. Deep brain stimulation in Tourette's syndrome. Movement Disorders 2007, 22: 1346-1350. PMID: 17580320, DOI: 10.1002/mds.21398.Peer-Reviewed Original ResearchConceptsDeep brain stimulationBilateral deep brain stimulationTourette syndromeBrain stimulationIntractable Tourette syndromeProgressive neurological impairmentAdult patientsSevere ticsObsessive-compulsive disorderNeurological impairmentMotor ticsMedial partSyndromeHead jerkThalamusStimulationPatientsImpairmentGood effect
2006
Patient selection and assessment recommendations for deep brain stimulation in Tourette syndrome
Mink JW, Walkup J, Frey KA, Como P, Cath D, DeLong MR, Erenberg G, Jankovic J, Juncos J, Leckman JF, Swerdlow N, Visser‐Vandewalle V, Vitek JL. Patient selection and assessment recommendations for deep brain stimulation in Tourette syndrome. Movement Disorders 2006, 21: 1831-1838. PMID: 16991144, DOI: 10.1002/mds.21039.Peer-Reviewed Original ResearchConceptsDeep brain stimulationTourette syndromeClinical trialsBrain stimulationClinical treatment choiceFuture clinical trialsTourette Syndrome AssociationEarly clinical experiencePotential clinical trialsSurgical candidatesPatient selectionTreatment choiceTic disordersSyndrome AssociationClinical careAlternative treatmentClinical experienceTic severityEarly useSyndromeAssessment recommendationsTrialsRecent publicityStimulationSurgery