2023
Utility of promoter hypermethylation in malignant risk stratification of intraductal papillary mucinous neoplasms
Chhoda A, Sharma A, Sailo B, Tang H, Ruzgar N, Tan W, Ying L, Khatri R, Narayanan A, Mane S, De Kumar B, Wood L, Iacobuzio-Donahue C, Wolfgang C, Kunstman J, Salem R, Farrell J, Ahuja N. Utility of promoter hypermethylation in malignant risk stratification of intraductal papillary mucinous neoplasms. Clinical Epigenetics 2023, 15: 28. PMID: 36803844, PMCID: PMC9942382, DOI: 10.1186/s13148-023-01429-5.Peer-Reviewed Original ResearchConceptsPapillary mucinous neoplasmMalignant risk stratificationCACNA1G geneRisk stratificationMucinous neoplasmsBiomarker panelBackgroundIntraductal papillary mucinous neoplasmIntraductal papillary mucinous neoplasmEarly detectionPrevious case-control studyHigh-grade dysplasiaCase-control studyPancreatic cancer precursorsReceiver Operating Characteristic (ROC) curve analysisSignificant diagnostic challengeCross-sectional imagingCharacteristic curve analysisOperating Characteristic curve analysisG geneHigh diagnostic specificityPrior validation studiesSignificant procedural riskIPMN tissuesSurgical resectionAdvanced neoplasia
2018
Incremental value of DNA analysis in pancreatic cysts stratified by clinical risk factors
Farrell J, Al-Haddad M, Jackson SA, Gonda T. Incremental value of DNA analysis in pancreatic cysts stratified by clinical risk factors. Gastrointestinal Endoscopy 2018, 89: 832-841.e2. PMID: 30447214, DOI: 10.1016/j.gie.2018.10.049.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaCyst FluidDNAEndoscopic Ultrasound-Guided Fine Needle AspirationFollow-Up StudiesGenes, Tumor SuppressorHumansKaplan-Meier EstimateLoss of HeterozygosityMutationPancreatic CystPancreatic NeoplasmsProportional Hazards ModelsProto-Oncogene Proteins p21(ras)Retrospective StudiesRisk AssessmentRisk FactorsSequence Analysis, DNASurvival AnalysisConceptsHigh-risk stigmataWorrisome featuresMalignancy riskPatient outcomesDNA abnormalitiesPredictive valueCyst fluid molecular analysisLong-term malignancy riskClinical risk factorsIncremental predictive valueCytologic malignancyClinical characteristicsFinal pathologyFree survivalSuch patientsPatient populationPancreatic cystsRisk factorsMalignant outcomeCyst fluidKras mutationsPatientsSurvival analysisAbnormalitiesTumor suppressor gene