2023
Pancreatic imaging findings from the PRECEDE study: A large high-risk heritable cohort for pancreatic cancer.
Haimi I, Zogopoulos G, Dettwyler S, Everett J, Bi Y, Brand R, Chung D, Farrell J, Grossberg A, Kastrinos F, Katona B, Klute K, Kupfer S, Lucas A, Paiella S, Parmigiani G, Permuth J, Sears R, Sussman D, Simeone D, Consortium P. Pancreatic imaging findings from the PRECEDE study: A large high-risk heritable cohort for pancreatic cancer. Journal Of Clinical Oncology 2023, 41: 689-689. DOI: 10.1200/jco.2023.41.4_suppl.689.Peer-Reviewed Original ResearchHigh-risk individualsPancreatic ductal adenocarcinomaPathogenic germline variantsFamilial pancreatic cancerCohort 1Worrisome featuresPancreatic cancerMain pancreatic duct diameterSolid massPancreatic duct diameterStandardized image acquisitionPGV groupGermline testingDuct stricturesIncurable stageMultiple cystsPancreatic abnormalitiesStandardized data collection systemNeuroendocrine tumorsDuctal adenocarcinomaCommon abnormalityFamily historyBenign lesionsLethal cancersPDAC risk
2022
Tu1185: DOES CURRENT EVIDENCE SUPPORT CYST GROWTH RATE AS A WORRISOME FEATURE? A SYSTEMATIC REVIEW AND META-ANALYSIS
Singh S, Chhoda A, Vodusek Z, Khatri R, Gunderson C, McCarty T, Sharma P, Grimshaw A, Kunstman J, Sharma A, Ahuja N, Gonda T, Farrell J. Tu1185: DOES CURRENT EVIDENCE SUPPORT CYST GROWTH RATE AS A WORRISOME FEATURE? A SYSTEMATIC REVIEW AND META-ANALYSIS. Gastroenterology 2022, 162: s-907. DOI: 10.1016/s0016-5085(22)62148-6.Peer-Reviewed Original Research
2018
Incremental value of DNA analysis in pancreatic cysts stratified by clinical risk factors
Farrell J, Al-Haddad M, Jackson SA, Gonda T. Incremental value of DNA analysis in pancreatic cysts stratified by clinical risk factors. Gastrointestinal Endoscopy 2018, 89: 832-841.e2. PMID: 30447214, DOI: 10.1016/j.gie.2018.10.049.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaCyst FluidDNAEndoscopic Ultrasound-Guided Fine Needle AspirationFollow-Up StudiesGenes, Tumor SuppressorHumansKaplan-Meier EstimateLoss of HeterozygosityMutationPancreatic CystPancreatic NeoplasmsProportional Hazards ModelsProto-Oncogene Proteins p21(ras)Retrospective StudiesRisk AssessmentRisk FactorsSequence Analysis, DNASurvival AnalysisConceptsHigh-risk stigmataWorrisome featuresMalignancy riskPatient outcomesDNA abnormalitiesPredictive valueCyst fluid molecular analysisLong-term malignancy riskClinical risk factorsIncremental predictive valueCytologic malignancyClinical characteristicsFinal pathologyFree survivalSuch patientsPatient populationPancreatic cystsRisk factorsMalignant outcomeCyst fluidKras mutationsPatientsSurvival analysisAbnormalitiesTumor suppressor gene