Olfactory and trigeminal routes of HSV-1 CNS infection with regional microglial heterogeneity
Niemeyer C, Merle L, Bubak A, Baxter B, Gentile Polese A, Colon-Reyes K, Vang S, Hassell J, Bruce K, Nagel M, Restrepo D. Olfactory and trigeminal routes of HSV-1 CNS infection with regional microglial heterogeneity. Journal Of Virology 2024, 98: e00968-24. PMID: 39475273, PMCID: PMC11575344, DOI: 10.1128/jvi.00968-24.Peer-Reviewed Original ResearchCentral nervous systemHerpes simplex virus type 1Trigeminal ganglionVirus type 1Olfactory epitheliumHSV-1Locus coeruleusHSV-1 CNS infectionBrain regionsImmune responseResponse to HSV-1Microglial activationType 1Spread of HSV-1Absence of viral antigenHSV-1 antigenHSV-1 spreadHSV-1 infectionC57BL/6 mouse modelCranial nerve nucleiResponse of macrophagesInflammatory response of macrophagesCNS infectionRaphe nucleusNasal epitheliaHigh-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats
de Noronha S, de Moraes L, Hassell J, Stamper C, Arnold M, Heinze J, Foxx C, Lieb M, Cler K, Karns B, Jaekel S, Loupy K, Silva F, Chianca-Jr. D, Lowry C, de Menezes R. High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats. Biological Research 2024, 57: 23. PMID: 38705984, PMCID: PMC11071217, DOI: 10.1186/s40659-024-00505-1.Peer-Reviewed Original ResearchConceptsDefensive behavioral responsesSerotonergic gene expressionDorsal raphe nucleusSlc6a4 mRNA expressionBehavioral responsesMicrobiome-gut-brainRaphe nucleusAnxiety-related behavioral responsesBrain serotonergic systemSerotonergic brain systemAnxiety-like behaviorMale ratsAxis signalingHigh-fat dietBrain systemsSerotonergic systemAssociated with stressCommunity compositionGut microbiomeGene expressionAbundance of BlautiaHTR1AGut microbiome diversityTPH2SLC6A4