2022
Concomitant medication use in children with autism spectrum disorder: Data from the Autism Biomarkers Consortium for Clinical Trials
Shurtz L, Schwartz C, DiStefano C, McPartland JC, Levin AR, Dawson G, Kleinhans NM, Faja S, Webb SJ, Shic F, Naples AJ, Seow H, Bernier RA, Chawarska K, Sugar CA, Dziura J, Senturk D, Santhosh M, Jeste SS. Concomitant medication use in children with autism spectrum disorder: Data from the Autism Biomarkers Consortium for Clinical Trials. Autism 2022, 27: 952-966. PMID: 36086805, PMCID: PMC9995606, DOI: 10.1177/13623613221121425.Peer-Reviewed Original ResearchConceptsConcomitant psychotropic medicationsPsychotropic medicationsClinical trialsMedication useSchool-aged childrenClinical representativenessSelective serotonin reuptake inhibitorsConcomitant medication useVariety of medicationsAutism spectrum disorderSerotonin reuptake inhibitorsPsychotropic medication useNew treatment optionsGreater overall impairmentCentral nervous systemSpectrum disorderMedication classesReuptake inhibitorsAlpha agonistsTreatment optionsClinical endpointsInclusion criteriaStudy populationMedicationsNervous systemThe Autism Biomarkers Consortium for Clinical Trials: Initial Evaluation of a Battery of Candidate EEG Biomarkers
Webb SJ, Naples AJ, Levin AR, Hellemann G, Borland H, Benton J, Carlos C, McAllister T, Santhosh M, Seow H, Atyabi A, Bernier R, Chawarska K, Dawson G, Dziura J, Faja S, Jeste S, Murias M, Nelson CA, Sabatos-DeVito M, Senturk D, Shic F, Sugar CA, McPartland JC. The Autism Biomarkers Consortium for Clinical Trials: Initial Evaluation of a Battery of Candidate EEG Biomarkers. American Journal Of Psychiatry 2022, 180: 41-49. PMID: 36000217, PMCID: PMC10027395, DOI: 10.1176/appi.ajp.21050485.Peer-Reviewed Original ResearchConceptsBiological motion perceptionAutism spectrum disorderResting-state activityMotion perceptionEEG biomarkersGroup discriminationPsychometric propertiesBasic psychometric propertiesASD groupASD diagnosisNeural responsesSpectrum disorderAlpha powerN170Naturalistic studyPerceptionMixed resultsTask latencyVEP amplitudeContext of useLimited attentionInconsistent resultsAcquisition rateDiscriminationBatteriesIdentifying Age Based Maturation in the ERP Response to Faces in Children With Autism: Implications for Developing Biomarkers for Use in Clinical Trials
Webb SJ, Emerman I, Sugar C, Senturk D, Naples AJ, Faja S, Benton J, Borland H, Carlos C, Levin AR, McAllister T, Santhosh M, Bernier RA, Chawarska K, Dawson G, Dziura J, Jeste S, Kleinhans N, Murias M, Sabatos-DeVito M, Shic F, McPartland JC, Trials T. Identifying Age Based Maturation in the ERP Response to Faces in Children With Autism: Implications for Developing Biomarkers for Use in Clinical Trials. Frontiers In Psychiatry 2022, 13: 841236. PMID: 35615454, PMCID: PMC9126041, DOI: 10.3389/fpsyt.2022.841236.Peer-Reviewed Original ResearchAutism spectrum disorderEvent-related potentialsUpright facesTypical developmentASD participantsASD groupProcessing of facesNon-verbal IQERP component latenciesVisual processing systemFace memoryFace processingERP responsesTD childrenAutism spectrumSocial skillsTD groupInversion effectSlower latenciesSpectrum disorderSpecificity effectsAge-related changesNeurodevelopmental conditionsNeural biomarkersComponent latenciesThe Autism Biomarkers Consortium for Clinical Trials: evaluation of a battery of candidate eye-tracking biomarkers for use in autism clinical trials
Shic F, Naples AJ, Barney EC, Chang SA, Li B, McAllister T, Kim M, Dommer KJ, Hasselmo S, Atyabi A, Wang Q, Helleman G, Levin AR, Seow H, Bernier R, Charwaska K, Dawson G, Dziura J, Faja S, Jeste SS, Johnson SP, Murias M, Nelson CA, Sabatos-DeVito M, Senturk D, Sugar CA, Webb SJ, McPartland JC. The Autism Biomarkers Consortium for Clinical Trials: evaluation of a battery of candidate eye-tracking biomarkers for use in autism clinical trials. Molecular Autism 2022, 13: 15. PMID: 35313957, PMCID: PMC10124777, DOI: 10.1186/s13229-021-00482-2.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderBiological motion preferenceSocial interactiveHuman faceMotion preferencesAutism symptom severityPragmatic communication skillsHigher verbal IQAttentional processesASD groupScene tasksVerbal IQTypical developmentSocial scenesSpectrum disorderOculomotor indicesReflex taskStandardized contextEye movementsCommunication skillsConstruct validitySymptom severityTaskPsychiatric conditionsSpecific interventions
2021
Direct observation in a large-scale randomized trial of parent training in children with autism spectrum disorder and disruptive behavior
Swiezy N, Smith T, Johnson CR, Bearss K, Lecavalier L, Drill R, Warner D, Deng Y, Xu Y, Dziura J, Handen B, Scahill L. Direct observation in a large-scale randomized trial of parent training in children with autism spectrum disorder and disruptive behavior. Research In Autism Spectrum Disorders 2021, 89: 101879. PMID: 34950225, PMCID: PMC8691726, DOI: 10.1016/j.rasd.2021.101879.Peer-Reviewed Original ResearchAutism spectrum disorderDisruptive behaviorParent trainingSpectrum disorderParent ratingsParentchild interactionChild behaviorObservation measuresResource-intensive effortsChild participantsParent educationYoung childrenSame measuresLaboratory settingChildrenSOAP dataPrimary measureMeasuresModerate levelsTrainingPrimary purposeDisordersStudy entry criteriaBehaviorOutcome measures
2019
Methodological considerations in the use of Noldus EthoVision XT video tracking of children with autism in multi-site studies
Sabatos-DeVito M, Murias M, Dawson G, Howell T, Yuan A, Marsan S, Bernier RA, Brandt CA, Chawarska K, Dzuira JD, Faja S, Jeste SS, Naples A, Nelson CA, Shic F, Sugar CA, Webb SJ, McPartland JC, Trials A. Methodological considerations in the use of Noldus EthoVision XT video tracking of children with autism in multi-site studies. Biological Psychology 2019, 146: 107712. PMID: 31163191, PMCID: PMC7334026, DOI: 10.1016/j.biopsycho.2019.05.012.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderBehavioral testing paradigmsVariety of behaviorsSpectrum disorderLaboratory-based observationsPlay interactionsBehavioral paradigmsBehavioral manifestationsSocial engagementMulti-site studyBehavioral phenotypesTesting paradigmTracking studyHuman movement patternsMethodological considerationsMovement patternsTranslational biomarkersParadigmChildrenAutismTracking dataVideo trackingRodent modelsContextRole of genetics
2016
Moderators of Parent Training for Disruptive Behaviors in Young Children with Autism Spectrum Disorder
Lecavalier L, Smith T, Johnson C, Bearss K, Swiezy N, Aman MG, Sukhodolsky DG, Deng Y, Dziura J, Scahill L. Moderators of Parent Training for Disruptive Behaviors in Young Children with Autism Spectrum Disorder. Research On Child And Adolescent Psychopathology 2016, 45: 1235-1245. PMID: 27917460, PMCID: PMC5459681, DOI: 10.1007/s10802-016-0233-x.Peer-Reviewed Original ResearchConceptsHome Situations QuestionnaireAutism spectrum disorderParent education programAttention deficit hyperactivity disorderParent trainingAberrant Behavior Checklist-Irritability subscaleSpectrum disorderClinical Global Impressions-Improvement scaleDisruptive behaviorOppositional defiant disorder symptomsASD symptom severityLow anxiety groupDeficit hyperactivity disorderYoung childrenADHD groupASD severityHyperactivity disorderAnxiety groupDisorder symptomsPotential moderatorsSituations QuestionnaireNoncompliant behaviorAge 3ModeratorSymptom severityEffect of Parent Training on Adaptive Behavior in Children With Autism Spectrum Disorder and Disruptive Behavior: Results of a Randomized Trial
Scahill L, Bearss K, Lecavalier L, Smith T, Swiezy N, Aman MG, Sukhodolsky DG, McCracken C, Minshawi N, Turner K, Levato L, Saulnier C, Dziura J, Johnson C. Effect of Parent Training on Adaptive Behavior in Children With Autism Spectrum Disorder and Disruptive Behavior: Results of a Randomized Trial. Journal Of The American Academy Of Child & Adolescent Psychiatry 2016, 55: 602-609.e3. PMID: 27343887, DOI: 10.1016/j.jaac.2016.05.001.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderParent training groupParent trainingDaily living skillsDisruptive behaviorAdaptive behaviorParent educationSpectrum disorderLiving skillsVineland Adaptive Behavior Scales-IIHigh-functioning childrenTraining groupGreater behavioral problemsYoung childrenIntellectual disabilityBehavior management strategiesAdaptive functioningSocialization domainsTelephone boosterBehavioral problemsScale IIDaily livingCommunication domainCore sessionsDaily living domainsWeight Gain and Metabolic Consequences of Risperidone in Young Children With Autism Spectrum Disorder
Scahill L, Jeon S, Boorin SJ, McDougle CJ, Aman MG, Dziura J, McCracken JT, Caprio S, Arnold LE, Nicol G, Deng Y, Challa SA, Vitiello B. Weight Gain and Metabolic Consequences of Risperidone in Young Children With Autism Spectrum Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2016, 55: 415-423. PMID: 27126856, PMCID: PMC4851735, DOI: 10.1016/j.jaac.2016.02.016.Peer-Reviewed Original ResearchConceptsWaist circumferenceWeight gainWeek 24Metabolic syndromeWeek 16Homeostatic model assessment-insulin resistanceMetabolic consequencesModel assessment-insulin resistanceBody mass index z-scoreAssessment-insulin resistanceLiver function testsTrial of risperidoneIndex z-scoreAutism spectrum disorderRapid weight gainRisperidone exposureBlood lipidsRisperidone monotherapyRisperidone treatmentFunction testsNormal weightInsulin resistanceAlanine aminotransferaseSpectrum disorderBlood samples
2015
Extended-Release Guanfacine for Hyperactivity in Children With Autism Spectrum Disorder
Scahill L, McCracken JT, King BH, Rockhill C, Shah B, Politte L, Sanders R, Minjarez M, Cowen J, Mullett J, Page C, Ward D, Deng Y, Loo S, Dziura J, McDougle CJ. Extended-Release Guanfacine for Hyperactivity in Children With Autism Spectrum Disorder. American Journal Of Psychiatry 2015, 172: 1197-1206. PMID: 26315981, DOI: 10.1176/appi.ajp.2015.15010055.Peer-Reviewed Original ResearchConceptsExtended-release guanfacineModal doseGuanfacine groupWeek 8Common adverse eventsAutism spectrum disorderWeeks of treatmentAttention deficit hyperactivity disorderDeficit hyperactivity disorderPlacebo groupAdverse eventsBlood pressurePlacebo subjectsClinical trialsSpectrum disorderPlaceboGuanfacineHyperactivityPulse rateHyperactivity disorderGroup differencesMotor planningWeeksBrief cognitive batteryDisordersEffect of Parent Training vs Parent Education on Behavioral Problems in Children With Autism Spectrum Disorder: A Randomized Clinical Trial
Bearss K, Johnson C, Smith T, Lecavalier L, Swiezy N, Aman M, McAdam DB, Butter E, Stillitano C, Minshawi N, Sukhodolsky DG, Mruzek DW, Turner K, Neal T, Hallett V, Mulick JA, Green B, Handen B, Deng Y, Dziura J, Scahill L. Effect of Parent Training vs Parent Education on Behavioral Problems in Children With Autism Spectrum Disorder: A Randomized Clinical Trial. JAMA 2015, 313: 1524-1533. PMID: 25898050, PMCID: PMC9078140, DOI: 10.1001/jama.2015.3150.Peer-Reviewed Original ResearchConceptsAberrant Behavior Checklist-Irritability subscaleClinical Global Impressions-Improvement scaleParent trainingCo-primary outcomesAutism spectrum disorderClinical Global ImpressionSpectrum disorderDisruptive behaviorParent-reported outcomesParent educationPositive responseClinical improvementSecondary outcomesWeek 24Global ImpressionBlinded cliniciansClinical trialsClinical significanceMAIN OUTCOMEImprovement ScaleGreater severityTreatment assignmentSensitivity of the modified Children’s Yale–Brown Obsessive Compulsive Scale to detect change: Results from two multi-site trials
Scahill L, Sukhodolsky DG, Anderberg E, Dimitropoulos A, Dziura J, Aman MG, McCracken J, Tierney E, Hallett V, Katz K, Vitiello B, McDougle C. Sensitivity of the modified Children’s Yale–Brown Obsessive Compulsive Scale to detect change: Results from two multi-site trials. Autism 2015, 20: 145-152. PMID: 25882391, DOI: 10.1177/1362361315574889.Peer-Reviewed Original Research
2012
Use of a Direct Observational Measure in a Trial of Risperidone and Parent Training in Children with Pervasive Developmental Disorders
Handen BL, Johnson CR, Butter EM, Lecavalier L, Scahill L, Aman MG, McDougle CJ, Arnold LE, Swiezy NB, Sukhodolsky DG, Mulick JA, White SW, Bearss K, Hollway JA, Stigler KA, Dziura J, Yu S, Sacco K, Vitiello B. Use of a Direct Observational Measure in a Trial of Risperidone and Parent Training in Children with Pervasive Developmental Disorders. Journal Of Developmental And Physical Disabilities 2012, 25: 355-371. PMID: 23730123, PMCID: PMC3665525, DOI: 10.1007/s10882-012-9316-y.Peer-Reviewed Original ResearchParent trainingPositive reinforcementChild's inappropriate behaviorParent-child interactionsAutism spectrum disorderDirect observational measuresTrial of risperidoneSerious behavior problemsPervasive developmental disorderAnalysis of covarianceClinician-based measuresParent behaviorSpectrum disorderObservational measuresAnalogue measuresBehavior problemsInappropriate behaviorDevelopmental disordersAnalog procedureParentsParental requestChildrenTreatment conditionsGreater useMeasuresBrief Report: Social Disability in Autism Spectrum Disorder: Results from Research Units on Pediatric Psychopharmacology (RUPP) Autism Network Trials
Scahill L, Hallett V, Aman MG, McDougle CJ, Eugene Arnold L, McCracken JT, Tierney E, Deng Y, Dziura J, Vitiello B, the Research Units on Pediatric Psychopharmacology (RUPP) Autism Network). Brief Report: Social Disability in Autism Spectrum Disorder: Results from Research Units on Pediatric Psychopharmacology (RUPP) Autism Network Trials. Journal Of Autism And Developmental Disorders 2012, 43: 739-746. PMID: 23104617, PMCID: PMC3886122, DOI: 10.1007/s10803-012-1689-3.Peer-Reviewed Original ResearchConceptsSocial Withdrawal subscaleSocial disabilityWithdrawal subscaleAcute treatment trialsWeeks of treatmentDouble-blind conditionsAutism spectrum disorderMedication trialsActive treatmentTreatment trialsSpectrum disorderNetwork trialSecondary analysisRisperidoneTrialsPlaceboDisabilityParent trainingSubjectsDisordersTreatmentSubscalesUseful measureResearch UnitWeeks