2008
Primary Defects in β-Cell Function Further Exacerbated by Worsening of Insulin Resistance Mark the Development of Impaired Glucose Tolerance in Obese Adolescents
Cali AM, Man CD, Cobelli C, Dziura J, Seyal A, Shaw M, Allen K, Chen S, Caprio S. Primary Defects in β-Cell Function Further Exacerbated by Worsening of Insulin Resistance Mark the Development of Impaired Glucose Tolerance in Obese Adolescents. Diabetes Care 2008, 32: 456-461. PMID: 19106382, PMCID: PMC2646028, DOI: 10.2337/dc08-1274.Peer-Reviewed Original ResearchConceptsImpaired glucose toleranceNormal glucose toleranceBeta-cell functionBeta-cell responsivityObese adolescentsGlucose toleranceDisposition indexOral glucose tolerance testProgressive declinePre-diabetic stateGlucose tolerance testBMI z-scorePrimary defectGlucose intoleranceGlucose areaTolerance testPlasma glucoseInsulin sensitivityC-peptideInsulin secretionNonprogressorsZ-scoreNatural historyProgressorsPercent fat
2004
Validation of Insulin Sensitivity Indices from Oral Glucose Tolerance Test Parameters in Obese Children and Adolescents
Yeckel CW, Weiss R, Dziura J, Taksali SE, Dufour S, Burgert TS, Tamborlane WV, Caprio S. Validation of Insulin Sensitivity Indices from Oral Glucose Tolerance Test Parameters in Obese Children and Adolescents. The Journal Of Clinical Endocrinology & Metabolism 2004, 89: 1096-1101. PMID: 15001593, DOI: 10.1210/jc.2003-031503.Peer-Reviewed Original ResearchConceptsWhole-body insulin sensitivity indexOral glucose tolerance testInsulin sensitivity indexIntramyocellular lipid contentInsulin sensitivityInsulin resistanceObese youthLarge cohortComposite whole body insulin sensitivity indexOral glucose tolerance test parametersSurrogate indexClamp-derived insulin sensitivityImpaired glucose toleranceGlucose tolerance testType 2 diabetesEuglycemic hyperinsulinemic clampInsulin sensitivity measurementsGlucose toleranceMetabolic syndromeObese childrenObese populationPoor functionPlasma glucoseTolerance testInsulin response
2003
Prediabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning
Weiss R, Dufour S, Taksali SE, Tamborlane WV, Petersen KF, Bonadonna RC, Boselli L, Barbetta G, Allen K, Rife F, Savoye M, Dziura J, Sherwin R, Shulman GI, Caprio S. Prediabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning. The Lancet 2003, 362: 951-957. PMID: 14511928, PMCID: PMC2995523, DOI: 10.1016/s0140-6736(03)14364-4.Peer-Reviewed Original ResearchConceptsImpaired glucose toleranceNormal glucose toleranceGlucose toleranceObese childrenInsulin resistanceObese adolescentsGlucose disposalInsulin sensitivitySevere peripheral insulin resistanceNon-oxidative glucose metabolismSubcutaneous fatH plasma glucose concentrationsAbdominal fat partitioningVisceral lipid contentsPeripheral glucose disposalHigher intramyocellular lipid contentAbdominal fat distributionDegree of obesityIntramyocellular lipid contentPeripheral insulin resistanceHigh visceral fatAbdominal subcutaneous fatEuglycaemic hyperinsulinaemic clampSevere insulin resistancePlasma glucose concentration