2008
Abdominal Obesity in Older Women: Potential Role for Disrupted Fatty Acid Reesterification in Insulin Resistance
Yeckel CW, Dziura J, DiPietro L. Abdominal Obesity in Older Women: Potential Role for Disrupted Fatty Acid Reesterification in Insulin Resistance. The Journal Of Clinical Endocrinology & Metabolism 2008, 93: 1285-1291. PMID: 18198225, PMCID: PMC2291490, DOI: 10.1210/jc.2007-1875.Peer-Reviewed Original ResearchConceptsFatty acid reesterificationPeripheral insulin resistanceAbdominal obesityInsulin resistanceHepatic glucose productionAbdominal adiposityOlder womenGlucose utilizationGeneral Clinical Research CenterBasal hepatic glucose productionGlucose productionFree fatty acid metabolismExcess abdominal adiposityPerturbed glucose metabolismGlucose-lowering medicationsHormone replacement therapyClinical Research CenterPeripheral glucose utilizationGlycerol appearance rateInactive older womenTotal body fatCross-sectional studyAbdominal circumference valuesInsulin-stimulated suppressionFree fatty acid ratio
2005
Exercise and improved insulin sensitivity in older women: evidence of the enduring benefits of higher intensity training
DiPietro L, Dziura J, Yeckel CW, Neufer PD. Exercise and improved insulin sensitivity in older women: evidence of the enduring benefits of higher intensity training. Journal Of Applied Physiology 2005, 100: 142-149. PMID: 16141382, DOI: 10.1152/japplphysiol.00474.2005.Peer-Reviewed Original ResearchConceptsHigh-intensity exercise trainingIntensity exercise trainingExercise trainingAerobic trainingInsulin sensitivityExercise volumeOlder womenGlucose utilizationModerate-intensity aerobic trainingTwo-step euglycemic-hyperinsulinemic clampInsulin-stimulated glucose utilizationHigh-intensity aerobic trainingDual-energy X-ray absorptiometryHigher insulin doseLower insulin doseHealthy older womenEuglycemic hyperinsulinemic clampLow-intensity exerciseTotal body fatAdipose tissue lipolysisImproved glucose utilizationX-ray absorptiometrySuppression of lipolysisFinal exercise boutInsulin-stimulated suppression