2001
Isolation of functional polarized bile duct units from mouse liver
Cho W, Mennone A, Boyer J. Isolation of functional polarized bile duct units from mouse liver. AJP Gastrointestinal And Liver Physiology 2001, 280: g241-g246. PMID: 11208546, DOI: 10.1152/ajpgi.2001.280.2.g241.Peer-Reviewed Original ResearchConceptsVasoactive intestinal peptideBile duct epitheliumMurine animal modelBile duct unitsPortal perfusionIntestinal peptideSecretory responseAnimal modelsBlunt dissectionDuct epitheliumSecretory stimuliFluid secretionDuct unitsCholangiocyte secretionFurther enzymatic digestionMouse liverSecretionMurine animalsIBDUMice
1999
Canalicular Export Pumps Traffic with Polymeric Immunoglobulin A Receptor on the Same Microtubule-associated Vesicle in Rat Liver*
Soroka C, Pate M, Boyer J. Canalicular Export Pumps Traffic with Polymeric Immunoglobulin A Receptor on the Same Microtubule-associated Vesicle in Rat Liver*. Journal Of Biological Chemistry 1999, 274: 26416-26424. PMID: 10473600, DOI: 10.1074/jbc.274.37.26416.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBile CanaliculiBiological TransportBiopolymersCells, CulturedLiverMicroscopy, ElectronMicrotubulesRatsReceptors, FcConceptsApical membrane proteinsMembrane proteinsMicrotubule-associated vesiclesSite of functionMembrane transport proteinsMembrane-bound vesiclesNon-hydrolyzable nucleotidesReceptor trafficMicrotubule motorsTransport proteinsIntermediate chainEssential pathwayPolymeric immunoglobulinsSame vesiclesTranscytotic vesiclesMultidrug resistance protein 2Protein 2Immunoelectron microscopyVesiclesMicrotubulesProteinVesicular transcytosisPathwayRat hepatocytesCanalicular export
1995
Isolation of small polarized bile duct units.
Mennone A, Alvaro D, Cho W, Boyer J. Isolation of small polarized bile duct units. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 6527-6531. PMID: 7541542, PMCID: PMC41551, DOI: 10.1073/pnas.92.14.6527.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-3-isobutylxanthine4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAnimalsBicarbonatesBile DuctsBucladesineChloridesCholestasisColforsinFluoresceinsGluconatesHydrogen-Ion ConcentrationKineticsLiverMaleMicroscopy, ElectronMicroscopy, VideoRatsRats, Sprague-DawleySecretinTime FactorsConceptsBile duct unitsInterlobular bile ductsBile ductDuct unitsSmall interlobular bile ductsBile duct syndromeBile duct segmentsCholestatic liver disordersCl-/HCO3- exchange activityRat liverLiver disordersPrimary siteForskolin administrationMicroM forskolinDextran 40Duct segmentsDibutyryl cAMPUseful preparationLiverSecretionForskolinImaging techniquesDuctLuminal spaceSyndrome
1990
Taurocholate stimulates transcytotic vesicular pathways labeled by horseradish peroxidase in the isolated perfused rat liver
Hayakawa T, Cheng O, Ma A, Boyer J. Taurocholate stimulates transcytotic vesicular pathways labeled by horseradish peroxidase in the isolated perfused rat liver. Gastroenterology 1990, 99: 216-228. PMID: 2344927, DOI: 10.1016/0016-5085(90)91251-z.Peer-Reviewed Original Research[34] Preparation of basolateral (sinusoidal) and canalicular plasma membrane vesicles for the study of hepatic transport processes
Meier P, Boyer J. [34] Preparation of basolateral (sinusoidal) and canalicular plasma membrane vesicles for the study of hepatic transport processes. Methods In Enzymology 1990, 192: 534-545. PMID: 1963666, DOI: 10.1016/0076-6879(90)92092-r.Peer-Reviewed Original Research
1989
Quantitative assessment of canalicular bile formation in isolated hepatocyte couplets using microscopic optical planimetry.
Gautam A, Ng O, Strazzabosco M, Boyer J. Quantitative assessment of canalicular bile formation in isolated hepatocyte couplets using microscopic optical planimetry. Journal Of Clinical Investigation 1989, 83: 565-573. PMID: 2913052, PMCID: PMC303716, DOI: 10.1172/jci113919.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBileBile CanaliculiBile Ducts, IntrahepaticLiverMicroscopy, ElectronRatsRats, Inbred StrainsTaurocholic AcidUrsodeoxycholic AcidConceptsIsolated rat hepatocyte couplets
1987
Isolated rat hepatocyte couplets in short‐term culture: Structural characteristics and plasma membrane reorganization
Gautam A, Ng O, Boyer J. Isolated rat hepatocyte couplets in short‐term culture: Structural characteristics and plasma membrane reorganization. Hepatology 1987, 7: 216-223. PMID: 3557300, DOI: 10.1002/hep.1840070203.Peer-Reviewed Original ResearchManganese-bilirubin cholestasis. Further studies in pathogenesis.
Witzleben C, Boyer J, Ng O. Manganese-bilirubin cholestasis. Further studies in pathogenesis. Laboratory Investigation 1987, 56: 151-4. PMID: 3807313.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBilirubinCholestasisFreeze FracturingGallbladderIntercellular JunctionsManganeseMicroscopy, ElectronRatsRats, GunnRats, Inbred Strains
1985
Formation of canalicular spaces in isolated rat hepatocyte couplets.
Boyer J, Ng O, Gautam A. Formation of canalicular spaces in isolated rat hepatocyte couplets. Proceedings Of The Association Of American Physicians 1985, 98: 21-9. PMID: 2430357.Peer-Reviewed Original Research
1984
Mechanisms of taurocholate transport in canalicular and basolateral rat liver plasma membrane vesicles. Evidence for an electrogenic canalicular organic anion carrier.
Meier P, St Meier-Abt A, Barrett C, Boyer J. Mechanisms of taurocholate transport in canalicular and basolateral rat liver plasma membrane vesicles. Evidence for an electrogenic canalicular organic anion carrier. Journal Of Biological Chemistry 1984, 259: 10614-10622. PMID: 6469975, DOI: 10.1016/s0021-9258(18)91006-9.Peer-Reviewed Original Research
1983
Structural integrity of hepatocyte tight junctions.
Easter D, Wade J, Boyer J. Structural integrity of hepatocyte tight junctions. Journal Of Cell Biology 1983, 96: 745-749. PMID: 6833382, PMCID: PMC2112395, DOI: 10.1083/jcb.96.3.745.Peer-Reviewed Original Research
1982
Effects of taurocholate on the size of mixed lipid micelles and their associations with pigment and proteins in rat bile
Reuben A, Howell K, Boyer J. Effects of taurocholate on the size of mixed lipid micelles and their associations with pigment and proteins in rat bile. Journal Of Lipid Research 1982, 23: 1039-1052. PMID: 7142812, DOI: 10.1016/s0022-2275(20)38077-9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBileBile PigmentsColloidsLipoproteinsMaleMicellesMicroscopy, ElectronMolecular WeightProteinsRatsRats, Inbred StrainsTaurocholic AcidConceptsLipid micellesMixed micellesElution profilesHigh molecular weight protein aggregatesMicelle sizeMicellesMicellar radiusMixed lipid micellesBile pigmentsWeight protein aggregatesRat bileSalt peakUnconjugated dyeColumn fractionsTaurocholate concentrationPigmentsSephadex G200 chromatographyConstituents of bileColumnDyeProtein aggregatesEffect of taurocholateChromatographyConcentrationMMStructure of tight junctions during Cl secretion in the perfused rectal gland of the dogfish shark
Forrest J, Boyer J, Ardito T, Murdaugh H, Wade J. Structure of tight junctions during Cl secretion in the perfused rectal gland of the dogfish shark. American Journal Of Physiology 1982, 242: c388-c392. PMID: 7081428, DOI: 10.1152/ajpcell.1982.242.5.c388.Peer-Reviewed Original ResearchDeterminants of biliary secretion in isolated perfused skate liver
Reed J, Smith N, Boyer J. Determinants of biliary secretion in isolated perfused skate liver. American Journal Of Physiology 1982, 242: g319-g325. PMID: 7065254, DOI: 10.1152/ajpgi.1982.242.4.g319.Peer-Reviewed Original ResearchPermeability characteristics of bile duct in the rat
Smith N, Boyer J. Permeability characteristics of bile duct in the rat. American Journal Of Physiology 1982, 242: g52-g57. PMID: 7058899, DOI: 10.1152/ajpgi.1982.242.1.g52.Peer-Reviewed Original Research
1978
Ultrastructural changes during cholestasis induced by chlorpromazine in the isolated perfused rat liver.
Hruban Z, Tavoloni N, Reed J, Boyer J. Ultrastructural changes during cholestasis induced by chlorpromazine in the isolated perfused rat liver. Cell Pathology 1978, 26: 289-305. PMID: 416590, DOI: 10.1007/bf02889557.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell MembraneChlorpromazineCholestasisLiverMaleMembranesMicroscopy, ElectronRatsVacuoles
1974
Ultrastructural changes in livers of two patients with hypervitaminosis A.
Hruban Z, Russell R, Boyer J, Glagov S, Bagheri S. Ultrastructural changes in livers of two patients with hypervitaminosis A. American Journal Of Pathology 1974, 76: 451-61. PMID: 4416771, PMCID: PMC1910880.Peer-Reviewed Original ResearchConceptsPerisinusoidal fibrosisDistinctive ultrastructural changesChronic hypervitaminosis ALipid-storing cellsUltrastructural changesHypervitaminosis AHypervitaminosis A.Blood flowCellular atrophyFibrosisIto cellsMesenchymal cellsPatientsBasement membraneLiverMassive accumulationCellsNumerous bundlesAtrophyLymphocytesBullaeImpairmentHepatic Injury from Chronic Hypervitaminosis a Resulting in Portal Hypertension and Ascites
Russell R, Boyer J, Bagheri S, Hruban Z. Hepatic Injury from Chronic Hypervitaminosis a Resulting in Portal Hypertension and Ascites. New England Journal Of Medicine 1974, 291: 435-440. PMID: 4843409, DOI: 10.1056/nejm197408292910903.Peer-Reviewed Original ResearchMeSH KeywordsAscitesBasement MembraneBiopsy, NeedleChemical and Drug Induced Liver InjuryCollagenFemaleHepatic VeinsHistocytochemistryHumansHypertension, PortalLipid MetabolismLiverLiver CirculationLiver CirrhosisMaleMicroscopy, ElectronMicroscopy, FluorescenceMiddle AgedSclerosisTime FactorsVitamin AConceptsPortal hypertensionHepatic blood flowChronic hypervitaminosis ALiver biopsy materialLipid storage cellsChronic hypervitaminosisFocal congestionVein sclerosisHepatic injuryPerisinusoidal fibrosisHypervitaminosis AChronic ingestionHepatic functionClinical signsHistologic examinationBlood flowUnusual lesionFrozen sectionsIto cellsPerisinusoidal spaceCirrhosisHypertensionAscitesVitaminLike material