2020
Adaptive Regulation of Hepatocyte Transporters in Cholestasis
Boyer J. Adaptive Regulation of Hepatocyte Transporters in Cholestasis. 2020, 378-389. DOI: 10.1002/9781119436812.ch31.Peer-Reviewed Original ResearchSignal transduction pathwaysAdaptive responseOrganic solute transporterSecretory polarityTranscription factorsTransduction pathwaysMolecular adaptationsSolute transportersCytoskeleton structureIntracellular vesiclesTarget genesMembrane transportersCellular eventsJunctional proteinsNuclear receptorsCanalicular domainCholestatic phenotypeTransportersTight junctionsVital functionsRegulationAdaptive regulationImportant ligandsEnzymatic reactionsBile salt synthesis
1998
Cyclic AMP stimulates sorting of the canalicular organic anion transporter (Mrp2/cMoat) to the apical domain in hepatocyte couplets
Roelofsen H, Soroka C, Keppler D, Boyer J. Cyclic AMP stimulates sorting of the canalicular organic anion transporter (Mrp2/cMoat) to the apical domain in hepatocyte couplets. Journal Of Cell Science 1998, 111: 1137-1145. PMID: 9512509, DOI: 10.1242/jcs.111.8.1137.Peer-Reviewed Original ResearchConceptsTransport proteinsApical membraneApical domainTransporter-containing vesiclesMultidrug resistance protein 2Protein 2Cell-cell contactMicrotubule-dependent fashionBasolateral plasma membraneApical proteinsEffect of cAMPVesicle trafficAnion transportersSecretory polarityOrganic anion transportersPlasma membraneCanalicular membraneAnion transport capacityTransport activityApical excretionApical poleCanalicular organic anion transportMultispecific organic anion transporterAmphiphilic organic anionsTransport function