1995
Vesicle targeting to the apical domain regulates bile excretory function in isolated rat hepatocyte couplets
Boyer J, Soroka C. Vesicle targeting to the apical domain regulates bile excretory function in isolated rat hepatocyte couplets. Gastroenterology 1995, 109: 1600-1611. PMID: 7557144, DOI: 10.1016/0016-5085(95)90649-5.Peer-Reviewed Original ResearchConceptsInsertion of vesiclesTranslocation of vesiclesMembrane transport activityVesicle trafficApical domainIsolated rat hepatocyte coupletsAcid transportersTransport activityNocodazoleRat hepatocyte coupletsVesiclesIndependent mechanismsEpithelial cellsBile acid transporterSite of residenceHepatocyte coupletsTransportersCanalicular membraneRat hepatocytesImmunocytochemical localizationCyclic monophosphateAdenosine triphosphataseBile excretory function
1991
The use of isolated rat hepatocyte couplets, microscopic optical planimetry and quantitative microfluorimetry in hepatobiliary physiology
Strazzabosco M, Boyer J, Crepaldi G. The use of isolated rat hepatocyte couplets, microscopic optical planimetry and quantitative microfluorimetry in hepatobiliary physiology. Cytotechnology 1991, 5: 88-89. PMID: 22358966, DOI: 10.1007/bf00736820.Peer-Reviewed Original ResearchEffect of UDCA on intracellular and biliary pH in isolated rat hepatocyte couplets and perfused livers
Strazzabosco M, Sakisaka S, Hayakawa T, Boyer J. Effect of UDCA on intracellular and biliary pH in isolated rat hepatocyte couplets and perfused livers. American Journal Of Physiology 1991, 260: g58-g69. PMID: 1987808, DOI: 10.1152/ajpgi.1991.260.1.g58.Peer-Reviewed Original ResearchConceptsBiliary HCO3- concentrationUrsodeoxycholic acidRat hepatocyte coupletsBiliary pHAcid loadEffect of UDCABile duct lumenHepatocyte coupletsIsolated rat hepatocyte coupletsBiliary epitheliumHCO3- concentrationDuct lumenRemoval of ClHCO3- exchangeRat liverLiverIPRLHepatocytesHypercholeresisPerfusateBileExcretionEpitheliumAmiloride
1989
Quantitative assessment of canalicular bile formation in isolated hepatocyte couplets using microscopic optical planimetry.
Gautam A, Ng O, Strazzabosco M, Boyer J. Quantitative assessment of canalicular bile formation in isolated hepatocyte couplets using microscopic optical planimetry. Journal Of Clinical Investigation 1989, 83: 565-573. PMID: 2913052, PMCID: PMC303716, DOI: 10.1172/jci113919.Peer-Reviewed Original ResearchConceptsIsolated rat hepatocyte couplets
1988
Mechanisms of Bile Secretion: lnsights from the Isolated Rat Hepatocyte Couplet
Boyer J, Gautam A, Graf J. Mechanisms of Bile Secretion: lnsights from the Isolated Rat Hepatocyte Couplet. Seminars In Liver Disease 1988, 8: 308-316. PMID: 2850606, DOI: 10.1055/s-2008-1040552.Peer-Reviewed Original ResearchConceptsIsolated rat hepatocyte coupletsRat hepatocyte coupletsBile formationCanalicular bile formation