2018
Role of the androgen signaling axis in genitourinary malignancies.
Shinder B, Shupe A, Lee G, Stein M, Kim I, Singer E. Role of the androgen signaling axis in genitourinary malignancies. Translational Cancer Research 2018, 7: 1135-1142. PMID: 30701159, PMCID: PMC6349041, DOI: 10.21037/tcr.2018.03.41.Peer-Reviewed Original ResearchRenal cell carcinomaGenitourinary malignanciesAndrogen receptorBladder cancerRole of ARAdvanced disease stateProstate cancer developmentNovel therapeutic strategiesCell carcinomaTherapeutic armamentariumTherapeutic strategiesMortality rateCancer developmentMalignancyAndrogensDisease statesCancerCarcinomaProstateArmamentariumMolecular biologyDiseaseProgressionRoleReceptors
2013
Therapeutic Role of Bmi-1 Inhibitors in Eliminating Prostate Tumor Stem Cells
Kim I, Bertino J, Sabaawy H. Therapeutic Role of Bmi-1 Inhibitors in Eliminating Prostate Tumor Stem Cells. 2013 DOI: 10.21236/ada598365.Peer-Reviewed Original ResearchProstate tumor-initiating cellsTumor-initiating cellsBmi-1Stem cellsTreatment of zebrafishCancer cell senescenceMouse xenograftsZebrafish xenograft modelCell cycle arrestG1 cell cycle arrestCellular senescenceTranslational inhibitorBmi-1 expressionTumor stem cellsCell senescenceCycle arrestCurrent therapiesTherapeutic roleProstate cancerInvasion abilityTherapeutic strategiesXenograft modelCD44hi cellsTumor growthMetastatic potential