Prostate cancer cell growth inhibition by tamoxifen is associated with inhibition of protein kinase C and induction of p21waf1/cip1
Rohlff C, Blagosklonny M, Kyle E, Kesari A, Kim I, Zelner D, Hakim F, Trepel J, Bergan R. Prostate cancer cell growth inhibition by tamoxifen is associated with inhibition of protein kinase C and induction of p21waf1/cip1. The Prostate 1998, 37: 51-59. PMID: 9721069, DOI: 10.1002/(sici)1097-0045(19980915)37:1<51::aid-pros8>3.0.co;2-b.Peer-Reviewed Original ResearchConceptsProstate cancer cell growthCancer cell growthProtein kinase CHormone-refractory prostate cancerProstate cancer cell growth inhibitionGrowth inhibitionInhibition of PKCG1/S phase cell cycle arrestTamoxifen-mediated growth inhibitionCancer cell growth inhibitionProstate cancer cellsPhase cell cycle arrestDU145 prostate cancer cellsS-phase cell cycle arrestRetinoblastoma protein levelsFlow cytometric analysisP21WAF1/CIP1Cell growth inhibitionTamoxifen treatmentCell cycle arrestCell growthProstate cancerKinase CCytometric analysisWestern blot