Radium Ra 223 dichloride in castration-resistant prostate cancer.
Joung J, Ha Y, Kim I. Radium Ra 223 dichloride in castration-resistant prostate cancer. Drugs Of Today 2013, 49: 483-90. PMID: 23977665, DOI: 10.1358/dot.2013.49.8.1968670.Peer-Reviewed Original ResearchConceptsRadium Ra 223 dichlorideCastration-resistant prostate cancerRa-223 dichlorideBone metastasesProstate cancerLarge randomized phase III trialsRandomized phase III trialMedian overall survivalPhase III trialsPlacebo groupIII trialsOverall survivalPreclinical studiesAntitumor effectsBone marrowCanine modelHigh biological effectPatientsMetastasisCancerBiological effectsKBq/Low toxicityRatsMarrow