2011
Bone morphogenetic protein 6-induced interleukin-1β expression in macrophages requires PU.1/Smad1 interaction
Lee G, Jung Y, Lee J, Kim W, Kim I. Bone morphogenetic protein 6-induced interleukin-1β expression in macrophages requires PU.1/Smad1 interaction. Molecular Immunology 2011, 48: 1540-1547. PMID: 21571370, DOI: 10.1016/j.molimm.2011.04.019.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Morphogenetic Protein 6Bone Morphogenetic Protein Receptors, Type IBone Morphogenetic Protein Receptors, Type IICells, CulturedExtracellular Signal-Regulated MAP KinasesFluorescent Antibody TechniqueImmunoblottingImmunoprecipitationInterleukin-1betaJNK Mitogen-Activated Protein KinasesMacrophagesMiceNitric Oxide Synthase Type IIProto-Oncogene ProteinsReverse Transcriptase Polymerase Chain ReactionSignal TransductionSmad1 ProteinTrans-Activators
2010
Induction of Interleukin-6 Expression by Bone Morphogenetic Protein-6 in Macrophages Requires Both SMAD and p38 Signaling Pathways*
Lee G, Kwon S, Lee J, Jeon S, Jang K, Choi H, Lee H, Kim W, Kim S, Kim I. Induction of Interleukin-6 Expression by Bone Morphogenetic Protein-6 in Macrophages Requires Both SMAD and p38 Signaling Pathways*. Journal Of Biological Chemistry 2010, 285: 39401-39408. PMID: 20889504, PMCID: PMC2998138, DOI: 10.1074/jbc.m110.103705.Peer-Reviewed Original ResearchConceptsBone morphogenetic protein 6BMP receptor type IIProtein 6Activin-like kinase 2Non-Smad pathwaysTranscription factor GATA4P38 Signaling PathwayTarget genesKnockdown experimentsKinase 2Signaling pathwaysSignaling mechanismReceptor type IISmadIntracellular levelsIL-6 inductionPathwayGrowth factorInductionExpressionInterleukin-6 expressionTranscriptionMacrophagesGenesGATA4
2009
Bone morphogenetic protein‐6 induces the expression of inducible nitric oxide synthase in macrophages
Kwon S, Lee G, Lee J, Kim W, Kim I. Bone morphogenetic protein‐6 induces the expression of inducible nitric oxide synthase in macrophages. Immunology 2009, 128: e758-e765. PMID: 19740337, PMCID: PMC2753926, DOI: 10.1111/j.1365-2567.2009.03079.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, NeutralizingBone Morphogenetic Protein 6Cells, CulturedCycloheximideDactinomycinHumansInterleukin-1betaMacrophages, PeritonealMiceNF-kappa BNitric Oxide Synthase Type IIProtein Synthesis InhibitorsRecombinant ProteinsSignal TransductionSmad ProteinsTumor Necrosis Factor-alphaConceptsBone morphogenetic proteinBMP-6Effects of BMPBone morphogenetic protein 6New protein synthesisMorphogenetic proteinsMurine macrophage cell lineMacrophage cell lineImportant regulatorProtein synthesisProtein 6Cell typesMouse peritoneal macrophagesCell linesActinomycin DNF-kappaBSmadExpressionDose-dependent mannerSynthaseNitric oxide synthasePathwayInductionInducible nitric oxide synthasePeritoneal macrophages