2019
Evidence of differential microbiomes in healing versus non‐healing diabetic foot ulcers prior to and following foot salvage therapy
MacDonald A, Brodell JD, Daiss JL, Schwarz EM, Oh I. Evidence of differential microbiomes in healing versus non‐healing diabetic foot ulcers prior to and following foot salvage therapy. Journal Of Orthopaedic Research® 2019, 37: 1596-1603. PMID: 30908702, PMCID: PMC6659747, DOI: 10.1002/jor.24279.Peer-Reviewed Original ResearchConceptsSalvage therapyQuantitative polymerase chain reactionClinical outcomesClinical toolErythrocyte sedimentation rateFurther surgical interventionC-reactive proteinLower extremity amputationDiabetic foot ulcersEventual clinical outcomeImportant prognostic informationImportant clinical toolDFU patientsFoot salvageFoot ulcersDiabetic footExtremity amputationSurgical interventionPatient counselingAntibiotic treatmentPolymerase chain reactionPrognostic informationClinical signsMicrobiome analysisClinical significance
2017
Clinical Application of Immunoassay for Identification of Staphylococcus aureus and Monitoring Treatment Response in Diabetic Foot Infection
Oh I, Smith B, Grier A, Gill S, Daiss J. Clinical Application of Immunoassay for Identification of Staphylococcus aureus and Monitoring Treatment Response in Diabetic Foot Infection. Foot & Ankle Orthopaedics 2017, 2: 2473011417s000065. DOI: 10.1177/2473011417s000065.Peer-Reviewed Original ResearchDiabetic foot infectionsFoot infectionsSA infectionsAntibiotic treatmentTreatment responseStaphylococcus aureusPathogenic activityAdequate prognostic informationNonspecific inflammatory markersIntravenous antibiotic treatmentWhole bloodMonitoring Treatment ResponseSigns of infectionStandard cultureAntibody-secreting cellsMicrobiome analysisFoot salvageSalvage therapySalvage treatmentSpecific diagnostic toolsInflammatory markersDiabetic patientsCounseling patientsClinical symptomsWeeks 0Microbiome Analysis for Assessments of Treatment Response and Salvage Prognosis in Infected Diabetic Foot Ulcers
MacDonald A, Oh I, Grier A, Smith B, Daiss J, Gill S. Microbiome Analysis for Assessments of Treatment Response and Salvage Prognosis in Infected Diabetic Foot Ulcers. Foot & Ankle Orthopaedics 2017, 2: 2473011417s000060. DOI: 10.1177/2473011417s000060.Peer-Reviewed Original ResearchIntravenous antibiotic treatmentAntibiotic treatmentNon-traumatic lower extremity amputationsInfected diabetic foot ulcersAdequate prognostic informationPoor prognostic signDiabetic foot ulcersLower extremity amputationSignificant differencesMicrobiome analysisDFU infectionsFoot salvageWagner classificationMedical comorbiditiesCounseling patientsFoot ulcersInitial presentationPrognostic signPrognostic valueActive infectionDiabetic footPrognostic informationClinical signsWeek 8Surgical decision