2021
Lower synaptic density is associated with psychiatric and cognitive alterations in obesity
Asch RH, Holmes SE, Jastreboff AM, Potenza MN, Baldassarri SR, Carson RE, Pietrzak RH, Esterlis I. Lower synaptic density is associated with psychiatric and cognitive alterations in obesity. Neuropsychopharmacology 2021, 47: 543-552. PMID: 34294874, PMCID: PMC8674236, DOI: 10.1038/s41386-021-01111-5.Peer-Reviewed Original ResearchConceptsStress-related psychiatric disordersBody mass indexLower synaptic densitySynaptic densityPsychiatric disordersPsychiatric diagnosisOverweight/obesityNormal-weight individualsNormal-weight participantsSerious medical conditionPositron emission tomographyStress-related psychopathologyDorsolateral prefrontal cortexOverweight/Mass indexWeight participantsWeight individualsHealthy controlsTension/anxietyAssociated symptomatologyMedical conditionsIntervention development effortsObesityCognitive alterationsPsychiatric groupsAcute cognitive effects of single-dose intravenous ketamine in major depressive and posttraumatic stress disorder
Davis MT, DellaGiogia N, Maruff P, Pietrzak RH, Esterlis I. Acute cognitive effects of single-dose intravenous ketamine in major depressive and posttraumatic stress disorder. Translational Psychiatry 2021, 11: 205. PMID: 33833217, PMCID: PMC8032778, DOI: 10.1038/s41398-021-01327-5.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderExecutive functionStress disorderCognitive functionSingle-dose intravenous ketamineAcute cognitive effectsLarge magnitude improvementsPTSD relativeCognitive measuresCognitive domainsPTSD individualsMemory performanceCognitive effectsYears of educationBaseline performanceCognitive declineHealthy controlsPsychiatric distressCognitive dysfunctionHC individualsHC groupDepressive symptomsMemory 2Subanesthetic doseMajor depressive
2020
Depression and Cognitive Dysfunction in Older U.S. Military Veterans: Moderating Effects of BDNF Val66Met Polymorphism and Physical Exercise
Pitts BL, Wen V, Whealin JM, Fogle BM, Southwick SM, Esterlis I, Pietrzak RH. Depression and Cognitive Dysfunction in Older U.S. Military Veterans: Moderating Effects of BDNF Val66Met Polymorphism and Physical Exercise. American Journal Of Geriatric Psychiatry 2020, 28: 959-967. PMID: 32122804, DOI: 10.1016/j.jagp.2020.02.001.Peer-Reviewed Original ResearchConceptsU.S. military veteransVisual learningCognitive functioningMet allele carriersMilitary veteransObjective measuresSubjective cognitive measuresSubjective measuresCognitive dysfunctionEffect of depressionVal66Met genotypeCognitive measuresCognitive AssessmentProcessing speedCognitive functionBDNF Val66Met polymorphismPhysical exerciseVal/ValBDNF Val66Met genotypeFunctioningTreatment effortsModerate decrementsAnalysis of covarianceInteractive effectsLearning