2021
In vivo imaging of retrovirus infection reveals a role for Siglec-1/CD169 in multiple routes of transmission
Haugh KA, Ladinsky MS, Ullah I, Stone HM, Pi R, Gilardet A, Grunst MW, Kumar P, Bjorkman PJ, Mothes W, Uchil PD. In vivo imaging of retrovirus infection reveals a role for Siglec-1/CD169 in multiple routes of transmission. ELife 2021, 10: e64179. PMID: 34223819, PMCID: PMC8298093, DOI: 10.7554/elife.64179.Peer-Reviewed Original ResearchConceptsSentinel macrophagesSiglec-1/CD169Immune surveillance functionCommon host factorMesenteric sacsPeyer's patchesGastrointestinal tractOral routeReporter virusRetrovirus transmissionRetrovirus infectionFrontline cellsRetroviral pathogenesisHost factorsBioluminescence imagingVirus entryIncoming virusInfectionRetrovirus life cycleCD169Early eventsMacrophagesMultiscale imaging approachVirusSurveillance functionModulating HIV-1 envelope glycoprotein conformation to decrease the HIV-1 reservoir
Rajashekar JK, Richard J, Beloor J, Prévost J, Anand SP, Beaudoin-Bussières G, Shan L, Herndler-Brandstetter D, Gendron-Lepage G, Medjahed H, Bourassa C, Gaudette F, Ullah I, Symmes K, Peric A, Lindemuth E, Bibollet-Ruche F, Park J, Chen HC, Kaufmann DE, Hahn BH, Sodroski J, Pazgier M, Flavell RA, Smith AB, Finzi A, Kumar P. Modulating HIV-1 envelope glycoprotein conformation to decrease the HIV-1 reservoir. Cell Host & Microbe 2021, 29: 904-916.e6. PMID: 34019804, PMCID: PMC8214472, DOI: 10.1016/j.chom.2021.04.014.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, NeutralizingAntibody-Dependent Cell CytotoxicityAntiviral AgentsCD4 AntigensCD4-Positive T-LymphocytesCell LineEnv Gene Products, Human Immunodeficiency VirusEpitopesFemaleGlycoproteinsHEK293 CellsHIV InfectionsHIV-1HumansImmunoglobulin Fc FragmentsKiller Cells, NaturalMaleMiceMice, SCIDModels, AnimalProtein ConformationVirus ReplicationConceptsAntibody-dependent cellular cytotoxicityHIV-1 reservoirFc effector functionsViral reboundHumanized miceHIV-1HIV-1-infected individualsHIV-1-infected cellsAutologous HIV-1Natural killer cellsCD4-mimetic compoundsHIV-1 replicationSmall CD4-mimetic compoundsART interruptionFunctional cureNK cellsKiller cellsCellular cytotoxicityTherapeutic utilityInfected individualsCD4mcVirus reservoirMiceViral envelopeAntibody recognitionPrevalence of clinical malaria and household characteristics of patients in tribal districts of Pakistan
Karim A, Yasir M, Ali T, Malik S, Ullah I, Qureshi N, Yuanting H, Azhar E, Jin H. Prevalence of clinical malaria and household characteristics of patients in tribal districts of Pakistan. PLOS Neglected Tropical Diseases 2021, 15: e0009371. PMID: 33939717, PMCID: PMC8118523, DOI: 10.1371/journal.pntd.0009371.Peer-Reviewed Original ResearchConceptsP. vivaxTribal districtPlasmodium speciesNational Malaria Control ProgrammeP. falciparum casesFrequency of complicationsHigh-burden districtsControl of malariaMalaria control programmesMalaria-suspected patientsPublic health concernSpecies of malariaStrong health infrastructureOccurrence of malariaMultiple convulsionsClinical malariaFalciparum casesSevere malariaSpread of malariaUncomplicated casesHigh prevalenceMalaria casesClinical investigationEpidemiological dataBlood samples
2020
Targeted Delivery of Recombinant Heat Shock Protein 27 to Cardiomyocytes Promotes Recovery from Myocardial Infarction
Kim N, Ullah I, Chung K, Lee D, Cha MJ, Ban H, Choi CS, Kim S, Hwang KC, Kumar P, Lee SK. Targeted Delivery of Recombinant Heat Shock Protein 27 to Cardiomyocytes Promotes Recovery from Myocardial Infarction. Molecular Pharmaceutics 2020, 17: 2034-2043. PMID: 32364395, DOI: 10.1021/acs.molpharmaceut.0c00192.Peer-Reviewed Original ResearchConceptsAT1 receptor antibodyIschemic heart diseaseIschemia/reperfusionMyocardial infarctionMI ratsReceptor antibodiesHeart diseaseAngiotensin II type 1 receptorII type 1 receptorType 1 receptorAreas of fibrosisHeat shock protein 27Cause of deathRat MI modelShock protein 27Hypoxia-induced apoptosisIschemic injuryTherapeutic optionsCardiac functionProtective effectPromotes recoveryCardiomyocyte deathNormal responseMI modelSystemic delivery