2024
Beta Spike-Presenting SARS-CoV-2 Virus-like Particle Vaccine Confers Broad Protection against Other VOCs in Mice
Ullah I, Symmes K, Keita K, Zhu L, Grunst M, Li W, Mothes W, Kumar P, Uchil P. Beta Spike-Presenting SARS-CoV-2 Virus-like Particle Vaccine Confers Broad Protection against Other VOCs in Mice. Vaccines 2024, 12: 1007. PMID: 39340037, PMCID: PMC11435481, DOI: 10.3390/vaccines12091007.Peer-Reviewed Original ResearchImmune responseVirus-like particlesBeta spikesCross-protective immune responsesSARS-CoV-2 immunitySARS-CoV-2Effective immune responseEffective humoral immune responseHumoral immune responseAncestral spikeT cellsVaccination regimenSARS-CoV-2 virus-like particlesVaccine platformMouse modelVariant spike proteinsOmicron spikeBeta variantDisease burdenNon-infectiousReduce virus spreadImmunityVariant spikesFusion glycoproteinSpike proteinBlocking Fas-signaling in adipocytes and hepatocytes prevents obesity-associated inflammation, insulin resistance, and hepatosteatosis
Bae S, Ullah I, Beloor J, Lim J, Chung K, Yi Y, Kang E, Yun G, Rhim T, Lee S. Blocking Fas-signaling in adipocytes and hepatocytes prevents obesity-associated inflammation, insulin resistance, and hepatosteatosis. Journal Of Industrial And Engineering Chemistry 2024, 135: 434-443. DOI: 10.1016/j.jiec.2024.01.055.Peer-Reviewed Original ResearchFas signalingObese mouse modelInhibit Fas signalingFas-mediated apoptosisObesity-associated inflammationFas-signalingInsulin resistanceAdipose tissueMouse modelHepatic steatosisMetabolic dysfunctionSystemic free fatty acidsPro-inflammatory cytokine secretionReduced apoptosisApoptosisFatty acidsReversible inflammationSystemic deliveryCytokine secretionLiver functionInflammatory pathwaysFree fatty acidsLiver steatosisInflammationHepatic triglycerideTargeted siRNA delivery to lung epithelia reduces airway inflammation in a mouse model of allergic asthma
Ullah I, Choi H, Choi C, Chung K, Jung J, Yun G, Heo S, Yi Y, Kang E, Kim S, Yoon H, Rhim T, Lee S. Targeted siRNA delivery to lung epithelia reduces airway inflammation in a mouse model of allergic asthma. Biotechnology And Bioprocess Engineering 2024, 29: 97-108. DOI: 10.1007/s12257-024-00027-3.Peer-Reviewed Original ResearchLung epithelial cellsEpithelial cellsAirway inflammationIL-4RAIL-13IL-4Mouse modelMouse model of allergic asthmaModel of allergic asthmaAllergic pulmonary inflammationCultured lung epithelial cellsReduce airway inflammationInterleukin (IL)-4Asthma mouse modelIL-4 receptorMulti-subunit receptorModel in vivoHypersecretion of mucusIL-4 signalingOvalbumin sensitizationTh2 cytokinesPulmonary inflammationAirway hyperresponsivenessAllergic asthmaLung epithelia
2022
Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities
Chen Y, Sun L, Ullah I, Beaudoin-Bussières G, Anand SP, Hederman AP, Tolbert WD, Sherburn R, Nguyen DN, Marchitto L, Ding S, Wu D, Luo Y, Gottumukkala S, Moran S, Kumar P, Piszczek G, Mothes W, Ackerman ME, Finzi A, Uchil PD, Gonzalez FJ, Pazgier M. Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities. Science Advances 2022, 8: eabn4188. PMID: 35857504, PMCID: PMC9278865, DOI: 10.1126/sciadv.abn4188.Peer-Reviewed Original ResearchAngiotensin-converting enzyme 2Soluble angiotensin-converting enzyme 2Fc effector functionsSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptorLethal SARS-CoV-2 infectionK18-hACE2 mouse modelSARS-CoV-2 infectionAntibody-dependent cellular cytotoxicitySARS-CoV-2 antiviralsFc effector activityCoV-2 infectionSARS-CoV-2 variantsHalf maximal inhibitory concentrationComplement depositionACE2-FcCellular cytotoxicityEnzyme 2Mouse modelTherapeutic activityInhibitory concentrationTherapeutic settingDirect neutralizationInfectionReceptorsEffect of neutralization