Featured Publications
Sex differences in outcomes after coronary artery bypass grafting: a pooled analysis of individual patient data
Gaudino M, Di Franco A, Alexander JH, Bakaeen F, Egorova N, Kurlansky P, Boening A, Chikwe J, Demetres M, Devereaux PJ, Diegeler A, Dimagli A, Flather M, Hameed I, Lamy A, Lawton JS, Reents W, Robinson NB, Audisio K, Rahouma M, Serruys PW, Hara H, Taggart DP, Girardi LN, Fremes SE, Benedetto U. Sex differences in outcomes after coronary artery bypass grafting: a pooled analysis of individual patient data. European Heart Journal 2021, 43: 18-28. PMID: 34338767, PMCID: PMC8851663, DOI: 10.1093/eurheartj/ehab504.Peer-Reviewed Original ResearchConceptsCoronary artery bypassIndividual patient dataMyocardial infarctionArtery bypassCause mortalityWorse outcomesMultiple arterial graftingPatient dataOff-pump surgeryOutcomes of womenCABG trialBaseline characteristicsPatients 75Secondary outcomesPrimary outcomeArterial graftingCox regressionPooled analysisSurgical techniqueHigh riskHigh incidenceSimilar mortalitySystematic reviewRisk adjustmentMortality
2023
A Systematic Review of Contemporary Randomized Trials in Cardiothoracic Surgery
Robinson N, Rahouma M, Audisio K, Cancelli G, Demetres M, Soletti G, Hameed I, Girardi L, Ruel M, Fremes S, Gaudino M. A Systematic Review of Contemporary Randomized Trials in Cardiothoracic Surgery. Annals Of Thoracic Surgery Short Reports 2023, 1: 537-541. DOI: 10.1016/j.atssr.2023.05.017.Peer-Reviewed Original ResearchCardiothoracic surgeryMost trialsPrimary outcomePrimary end pointComposite primary outcomeMajor clinical eventsMedian fragility indexEligible trialsRandomized trialsTrial armsClinical eventsContemporary trialsFavorable outcomePatient outcomesTrial characteristicsMedian numberSurgeon experienceResults NinetyGeneral surgeryHigh riskSuperiority designSurgerySystematic reviewEnd pointTrials
2021
Characteristics of Randomized Clinical Trials in Surgery From 2008 to 2020
Robinson NB, Fremes S, Hameed I, Rahouma M, Weidenmann V, Demetres M, Morsi M, Soletti G, Di Franco A, Zenati MA, Raja SG, Moher D, Bakaeen F, Chikwe J, Bhatt DL, Kurlansky P, Girardi LN, Gaudino M. Characteristics of Randomized Clinical Trials in Surgery From 2008 to 2020. JAMA Network Open 2021, 4: e2114494. PMID: 34190996, PMCID: PMC8246313, DOI: 10.1001/jamanetworkopen.2021.14494.Peer-Reviewed Original ResearchConceptsMost trialsClinical eventsSurgical interventionSurgical RCTsClinical trialsSurgeon experienceMinor clinical eventsMore surgical interventionsReporting biasMajor clinical eventsRandomized clinical trialsRisk of biasMedian fragility indexMedian sample sizeLarge treatment effectsPrimary outcomeTRIAL REGISTRATIONControl armTrial characteristicsSurgical trialsHigh riskSuperiority designConcerns of biasPrimary analysisRCTs