2024
Prognostic and therapeutic insights into MIF, DDT, and CD74 in melanoma
Valdez C, Sánchez-Zuno G, Osmani L, Ibrahim W, Galan A, Bacchiocchi A, Halaban R, Kulkarni R, Kang I, Bucala R, Tran T. Prognostic and therapeutic insights into MIF, DDT, and CD74 in melanoma. Oncotarget 2024, 15: 507-520. PMID: 39028303, PMCID: PMC11259151, DOI: 10.18632/oncotarget.28615.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntigens, Differentiation, B-LymphocyteBiomarkers, TumorFemaleHistocompatibility Antigens Class IIHumansImmune Checkpoint InhibitorsIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMaleMelanomaMiddle AgedMutationPrognosisRetrospective StudiesSkin NeoplasmsConceptsMacrophage migration inhibitory factorImmune checkpoint inhibitionD-dopachrome tautomeraseExpression of macrophage migration inhibitory factorDrivers of tumor progressionInflammatory cell markersPatient tumor samplesPatient survival outcomesMigration inhibitory factorStatistically significant differenceCheckpoint inhibitionImmune therapyPrognostic valueSurvival outcomesResistant melanomaGene expressionImproved survivalRetrospective studyInflammatory markersTumor progressionCell markersTumor samplesClinical evidenceMelanomaBulk RNA sequencingIL-1 receptor 1 signaling shapes the development of viral antigen-specific CD4+ T cell responses following COVID-19 mRNA vaccination
Park H, Shin M, Shin J, Kim H, Kang B, Par-Young J, Unlu S, Afinogenova Y, Catanzaro J, Young J, Kim M, Lee S, Jeon S, You S, Racke M, Bucala R, Kang I. IL-1 receptor 1 signaling shapes the development of viral antigen-specific CD4+ T cell responses following COVID-19 mRNA vaccination. EBioMedicine 2024, 103: 105114. PMID: 38640835, PMCID: PMC11041015, DOI: 10.1016/j.ebiom.2024.105114.Peer-Reviewed Original ResearchConceptsCD4<sup>+</sup> T cellsCOVID-19 mRNA vaccinesAntigen-specific CD4<sup>+</sup> T cell responsesT cell responsesPrimary antibody deficiencyCD4<sup>+</sup> T cell responsesT cellsIL-1R1MRNA vaccinesIL-1IgG antibodiesAntigen-specific CD4<sup>+</sup> T cellsCD4+ T cell responsesLevels of IL-1R1Human CD4<sup>+</sup> T cellsIL-1 receptor 1Healthy individualsDose of COVID-19 mRNA vaccineAntigen-specific CD4IL-1R1 expressionT cell immunityRepetitive antigenic stimulationCytokines interleukin (IL)-1Immune response to virusesExpression of IL-1R1
2020
IL-7 receptor alpha defines heterogeneity and signature of human effector memory CD8+ T cells in high dimensional analysis
Shin MS, Kim D, Yim K, Park HJ, You S, Dong X, Koumpouras F, Shaw AC, Fan R, Krishnaswamy S, Kang I. IL-7 receptor alpha defines heterogeneity and signature of human effector memory CD8+ T cells in high dimensional analysis. Cellular Immunology 2020, 355: 104155. PMID: 32619811, PMCID: PMC7415611, DOI: 10.1016/j.cellimm.2020.104155.Peer-Reviewed Original ResearchConceptsSingle-cell RNA-seqHuman effector memory CD8Effector memory CD8T cellsIL-7RαMemory CD8Gene regulationTranscription factorsRNA-seqPossible biological significanceDownstream eventsEM CD8Expression patternsExpressional relationshipDifferential expressionCytokine receptorsComprehensive landscapeHigh-dimensional cytometryBiological significanceIL-7 receptor alphaKey moleculesIL-7 receptor alpha chainReceptor alpha chainBiological implicationsHeterogeneous cell subsetsImmunological and Clinical Phenotyping in Primary Antibody Deficiencies: a Growing Disease Spectrum
Shin JJ, Liauw D, Siddiqui S, Lee J, Chung EJ, Steele R, Hsu FI, Price C, Kang I. Immunological and Clinical Phenotyping in Primary Antibody Deficiencies: a Growing Disease Spectrum. Journal Of Clinical Immunology 2020, 40: 592-601. PMID: 32239366, PMCID: PMC7260109, DOI: 10.1007/s10875-020-00773-y.Peer-Reviewed Original ResearchConceptsCommon variable immunodeficiencyInterstitial lung diseasePrimary antibody deficiencyConnective tissue diseaseAntibody deficiencyLow NK cell countHematopoietic malignanciesNon-infectious complicationsNon-infectious manifestationsNK cell countsNatural killer cellsPneumococcal vaccine responsesElectronic medical recordsResultsAll patientsImmune alterationsVaccine responsesKiller cellsTissue diseaseImmunoglobulin levelsVariable immunodeficiencyLung diseasePAD groupIgG deficiencyImmunological profileMedical records
2019
Transcriptomic analysis of human IL‐7 receptor alpha low and high effector memory CD8+ T cells reveals an age‐associated signature linked to influenza vaccine response in older adults
Park H, Shin MS, Kim M, Bilsborrow JB, Mohanty S, Montgomery RR, Shaw AC, You S, Kang I. Transcriptomic analysis of human IL‐7 receptor alpha low and high effector memory CD8+ T cells reveals an age‐associated signature linked to influenza vaccine response in older adults. Aging Cell 2019, 18: e12960. PMID: 31044512, PMCID: PMC6612637, DOI: 10.1111/acel.12960.Peer-Reviewed Original ResearchConceptsPeripheral blood cellsPeripheral blood mononuclear cellsEffector memory CD8Influenza vaccine responsesEM CD8T cellsIL-7RαMemory CD8Vaccine responsesBlood cellsOlder adultsIL-7 receptor alphaSignature genesBlood mononuclear cellsHuman peripheral whole bloodAge-associated expansionPeripheral whole bloodGene expression profilesAge-associated changesMeta-analysis studyGlobal transcriptomic profilesMononuclear cellsCD8Receptor alphaExpression profiles
2014
IL-6 Receptor α Defines Effector Memory CD8+ T Cells Producing Th2 Cytokines and Expanding in Asthma
Lee N, You S, Shin MS, Lee WW, Kang KS, Kim SH, Kim WU, Homer RJ, Kang MJ, Montgomery RR, Dela Cruz CS, Shaw AC, Lee PJ, Chupp GL, Hwang D, Kang I. IL-6 Receptor α Defines Effector Memory CD8+ T Cells Producing Th2 Cytokines and Expanding in Asthma. American Journal Of Respiratory And Critical Care Medicine 2014, 190: 1383-1394. PMID: 25390970, PMCID: PMC4299645, DOI: 10.1164/rccm.201403-0601oc.Peer-Reviewed Original ResearchConceptsEffector memory CD8EM CD8T cellsPeripheral bloodMemory CD8IL-13IL-5IL-6RαTh2-type cytokine IL-5Different T cell subsetsLevels of GATA3Frequency of ILT cell subsetsTh2-type cytokinesHealthy control subjectsRespiratory syncytial virusT cell populationsCytokines IL-5IL-6 receptor αIL-6Rα expressionHuman peripheral bloodEffector CD8Syncytial virusTh2 cytokinesCell subsets
2011
Age-associated alteration in naive and memory Th17 cell response in humans
Lee JS, Lee WW, Kim SH, Kang Y, Lee N, Shin MS, Kang SW, Kang I. Age-associated alteration in naive and memory Th17 cell response in humans. Clinical Immunology 2011, 140: 84-91. PMID: 21489886, PMCID: PMC3115516, DOI: 10.1016/j.clim.2011.03.018.Peer-Reviewed Original ResearchConceptsIL-17 productionT cellsCell responsesIL-17-producing cellsMemory cell subsetsHealthy elderly peopleHealthy young peopleAge-associated alterationsIL-17Results of ELISAEffector cellsCell subsetsDecreased frequencyHost defenseFlow cytometrySimilar findingsElderly peopleSimilar frequencyIFNCellsHumansFindingsELISAYoung peopleCytometry
2010
Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus
Shah K, Lee WW, Lee SH, Kim SH, Kang SW, Craft J, Kang I. Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus. Arthritis Research & Therapy 2010, 12: r53. PMID: 20334681, PMCID: PMC2888202, DOI: 10.1186/ar2964.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusSLE Disease Activity Index (SLEDAI) scorePeripheral blood mononuclear cellsTh17-polarizing cytokinesTh1 cell responsesDisease activityT cellsHealthy subjectsIL-17Th1 cellsCell responsesPhorbol myristate acetateTh17 cellsLupus erythematosusIL-6Plasma levelsDisease activity index scoreBalance of CD4Balance of Th17Expression of Th17Th17 cell responseActivity index scoreFrequency of CD4Chemokine receptor CCR4Blood mononuclear cells
2005
Altered IL-7Rα expression with aging and the potential implications of IL-7 therapy on CD8+ T-cell immune responses
Kim HR, Hong MS, Dan JM, Kang I. Altered IL-7Rα expression with aging and the potential implications of IL-7 therapy on CD8+ T-cell immune responses. Blood 2005, 107: 2855-2862. PMID: 16357322, PMCID: PMC1440715, DOI: 10.1182/blood-2005-09-3560.Peer-Reviewed Original ResearchConceptsIL-7 therapyT cellsT cell receptorIL-7T cell immune responsesEffector memory CD8T cell immunityT cell subsetsIL-7Rα expressionDiverse TCR repertoireIL-7Ralpha expressionIL-7Ralpha mRNAMemory CD8TCR repertoireElderly subjectsCD8Immune responseSurvival responseYoung subjectsImpaired signalingSTAT5 phosphorylationTherapyProtein alphaSurvival pathwaysCells
2004
Defective Control of Latent Epstein-Barr Virus Infection in Systemic Lupus Erythematosus
Kang I, Quan T, Nolasco H, Park SH, Hong MS, Crouch J, Pamer EG, Howe JG, Craft J. Defective Control of Latent Epstein-Barr Virus Infection in Systemic Lupus Erythematosus. The Journal Of Immunology 2004, 172: 1287-1294. PMID: 14707107, DOI: 10.4049/jimmunol.172.2.1287.Peer-Reviewed Original ResearchMeSH KeywordsAdultB-Lymphocyte SubsetsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCytomegalovirusEpitopes, T-LymphocyteEpstein-Barr Virus InfectionsFemaleHerpesvirus 4, HumanHumansLeukocytes, MononuclearLupus Erythematosus, SystemicLymphocyte CountMaleMiddle AgedSeverity of Illness IndexViral LoadVirus LatencyConceptsSystemic lupus erythematosusEBV viral loadT cell responsesViral loadT cellsIFN-gammaCell responsesEBV infectionLupus erythematosusHealthy controlsEBV-specific T-cell responsesVirus-specific T cell responsesLatent Epstein-Barr virus (EBV) infectionEBV-specific immune responsesEpstein-Barr virus infectionAltered T-cell responsesDefective controlFrequency of CD69HLA-A2 tetramersTetramer-positive CD8Latent EBV infectionEBV-specificImmunosuppressive medicationsDisease activityLupus patients
2000
Anserine Bursitis in Patients With Osteoarthritis of the Knee
KANG I, HAN S. Anserine Bursitis in Patients With Osteoarthritis of the Knee. Southern Medical Journal 2000, 93: 207-209. PMID: 10701790, DOI: 10.1097/00007611-200002000-00011.Peer-Reviewed Original Research
1998
Modulation of Murine Lyme Borreliosis by Interruption of the B7/CD28 T-Cell Costimulatory Pathway
Shanafelt M, Kang I, Barthold S, Bockenstedt L. Modulation of Murine Lyme Borreliosis by Interruption of the B7/CD28 T-Cell Costimulatory Pathway. Infection And Immunity 1998, 66: 266-271. PMID: 9423867, PMCID: PMC107886, DOI: 10.1128/iai.66.1.266-271.1998.Peer-Reviewed Original ResearchAbataceptAnimalsAntibodies, BacterialAntibodies, BlockingAntigens, CDAntigens, DifferentiationArthritis, InfectiousB7-1 AntigenB7-2 AntigenCD28 AntigensCTLA-4 AntigenFemaleImmunoconjugatesImmunoglobulin GInterferon-gammaInterleukin-4Lyme DiseaseLymphocyte ActivationMembrane GlycoproteinsMiceMice, Inbred BALB CSpecific Pathogen-Free OrganismsTh1 CellsTh2 CellsUp-Regulation