2018
Macrophage Migration Inhibitory Factor Regulates U1 Small Nuclear RNP Immune Complex–Mediated Activation of the NLRP3 Inflammasome
Shin MS, Kang Y, Wahl ER, Park HJ, Lazova R, Leng L, Mamula M, Krishnaswamy S, Bucala R, Kang I. Macrophage Migration Inhibitory Factor Regulates U1 Small Nuclear RNP Immune Complex–Mediated Activation of the NLRP3 Inflammasome. Arthritis & Rheumatology 2018, 71: 109-120. PMID: 30009530, PMCID: PMC6310104, DOI: 10.1002/art.40672.Peer-Reviewed Original ResearchMeSH KeywordsAntigen-Antibody ComplexAutoantibodiesBlotting, WesternCARD Signaling Adaptor ProteinsEnzyme-Linked Immunosorbent AssayFlow CytometryHumansInflammasomesInterleukin-1betaIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMass SpectrometryMonocytesNLR Family, Pyrin Domain-Containing 3 ProteinReceptors, ImmunologicRibonucleoprotein, U1 Small NuclearConceptsMacrophage migration inhibitory factorSystemic lupus erythematosusMigration inhibitory factorNLRP3 inflammasome activationImmune complexesIL-1βNLRP3 inflammasomeHuman monocytesInflammasome activationExpression of MIFProduction of MIFInhibitory factorCaspase-1IL-1β levelsIL-1β productionEnzyme-linked immunosorbentQuantitative polymerase chain reactionHigh expression alleleLupus patientsMIF productionMIF receptorInflammatory characteristicsLupus erythematosusInterleukin-1βPolymerase chain reaction
2013
Self Double-Stranded (ds)DNA Induces IL-1β Production from Human Monocytes by Activating NLRP3 Inflammasome in the Presence of Anti–dsDNA Antibodies
Shin MS, Kang Y, Lee N, Wahl ER, Kim SH, Kang KS, Lazova R, Kang I. Self Double-Stranded (ds)DNA Induces IL-1β Production from Human Monocytes by Activating NLRP3 Inflammasome in the Presence of Anti–dsDNA Antibodies. The Journal Of Immunology 2013, 190: 1407-1415. PMID: 23315075, PMCID: PMC3563755, DOI: 10.4049/jimmunol.1201195.Peer-Reviewed Original ResearchConceptsIL-1β productionIL-1βHuman monocytesReactive oxygen speciesOligomerization domain-like receptor family pyrinCell responsesProinflammatory cytokines IL-1βTh17 cell responseIL-17 productionAnti-dsDNA antibodiesSystemic lupus erythematosusInnate immune cellsAnti-dsDNA AbsPathogenesis of lupusCytokines IL-1βLupus pathogenesisLupus patientsFamily pyrinLupus erythematosusAutoimmune responseCutaneous lesionsImmune cellsT cellsNuclear AgsPathogenic hallmark
2012
U1-Small Nuclear Ribonucleoprotein Activates the NLRP3 Inflammasome in Human Monocytes
Shin MS, Kang Y, Lee N, Kim SH, Kang KS, Lazova R, Kang I. U1-Small Nuclear Ribonucleoprotein Activates the NLRP3 Inflammasome in Human Monocytes. The Journal Of Immunology 2012, 188: 4769-4775. PMID: 22490866, PMCID: PMC3347773, DOI: 10.4049/jimmunol.1103355.Peer-Reviewed Original ResearchConceptsU1 snRNPNuclear ribonucleoproteinSystemic lupus erythematosusIL-1β productionU1 small nuclear RNAU1 small nuclear ribonucleoproteinSmall nuclear ribonucleoproteinCytosolic protein complexesLupus erythematosusAutoimmune diseasesProtein complexesMicrobial nucleic acidsNuclear RNAPre-mRNAHuman monocytesNOD-like receptor familyReactive oxygen speciesEndogenous DNAReceptor familyMolecular complexesOxygen speciesRibonucleoproteinTLR7/8 pathwayIL-1βNuclear molecules
2009
Regulating human Th17 cells via differential expression of IL-1 receptor
Lee WW, Kang SW, Choi J, Lee SH, Shah K, Eynon EE, Flavell RA, Kang I. Regulating human Th17 cells via differential expression of IL-1 receptor. Blood 2009, 115: 530-540. PMID: 19965648, PMCID: PMC2810985, DOI: 10.1182/blood-2009-08-236521.Peer-Reviewed Original ResearchConceptsT cellsIL-1RICell differentiationDifferential expressionIL-17IL-15IL-1betaIL-7T cell receptor triggeringT helper 17 (Th17) cellsIL-1 receptor expressionIL-1RI expressionIL-17 productionHelper 17 cellsT cell populationsCytokine IL-7IL-1R antagonistIL-1 receptorUmbilical cord bloodHuman peripheral bloodGene expressionReceptor triggeringPeripheral bloodCord bloodReceptor expression