1,25-Dihyroxyvitamin D3 Promotes FOXP3 Expression via Binding to Vitamin D Response Elements in Its Conserved Noncoding Sequence Region
Kang SW, Kim SH, Lee N, Lee WW, Hwang KA, Shin MS, Lee SH, Kim WU, Kang I. 1,25-Dihyroxyvitamin D3 Promotes FOXP3 Expression via Binding to Vitamin D Response Elements in Its Conserved Noncoding Sequence Region. The Journal Of Immunology 2012, 188: 5276-5282. PMID: 22529297, PMCID: PMC3358577, DOI: 10.4049/jimmunol.1101211.Peer-Reviewed Original ResearchConceptsFoxp3 expressionT cellsVD receptorFOXP3 geneVD response elementsTreg cellsIL-2Foxp3-positive regulatory T cellsFoxp3 promoter activityHuman FOXP3 geneRegulatory T cellsImmune regulatory propertiesInhibitory functionHuman immune responseVitamin D response elementTCR triggeringD response elementImmune cellsImmune responseResponse elementUnique subsetRetinoic acidProliferation of targetsCellsExpression