Altered IL-7Rα expression with aging and the potential implications of IL-7 therapy on CD8+ T-cell immune responses
Kim HR, Hong MS, Dan JM, Kang I. Altered IL-7Rα expression with aging and the potential implications of IL-7 therapy on CD8+ T-cell immune responses. Blood 2005, 107: 2855-2862. PMID: 16357322, PMCID: PMC1440715, DOI: 10.1182/blood-2005-09-3560.Peer-Reviewed Original ResearchConceptsIL-7 therapyT cellsT cell receptorIL-7T cell immune responsesEffector memory CD8T cell immunityT cell subsetsIL-7Rα expressionDiverse TCR repertoireIL-7Ralpha expressionIL-7Ralpha mRNAMemory CD8TCR repertoireElderly subjectsCD8Immune responseSurvival responseYoung subjectsImpaired signalingSTAT5 phosphorylationTherapyProtein alphaSurvival pathwaysCells