2012
1,25-Dihyroxyvitamin D3 Promotes FOXP3 Expression via Binding to Vitamin D Response Elements in Its Conserved Noncoding Sequence Region
Kang SW, Kim SH, Lee N, Lee WW, Hwang KA, Shin MS, Lee SH, Kim WU, Kang I. 1,25-Dihyroxyvitamin D3 Promotes FOXP3 Expression via Binding to Vitamin D Response Elements in Its Conserved Noncoding Sequence Region. The Journal Of Immunology 2012, 188: 5276-5282. PMID: 22529297, PMCID: PMC3358577, DOI: 10.4049/jimmunol.1101211.Peer-Reviewed Original ResearchConceptsFoxp3 expressionT cellsVD receptorFOXP3 geneVD response elementsTreg cellsIL-2Foxp3-positive regulatory T cellsFoxp3 promoter activityHuman FOXP3 geneRegulatory T cellsImmune regulatory propertiesInhibitory functionHuman immune responseVitamin D response elementTCR triggeringD response elementImmune cellsImmune responseResponse elementUnique subsetRetinoic acidProliferation of targetsCellsExpression
2010
1,25-dihyroxyvitamin D3 enhances the activity of the FOXP3 gene in human CD4+ T cells through directly binding to putative VDRE sites in the FOXP3 gene (49.2)
Kang I, Kim S, Lee W, Kang S, Lee J. 1,25-dihyroxyvitamin D3 enhances the activity of the FOXP3 gene in human CD4+ T cells through directly binding to putative VDRE sites in the FOXP3 gene (49.2). The Journal Of Immunology 2010, 184: 49.2-49.2. DOI: 10.4049/jimmunol.184.supp.49.2.Peer-Reviewed Original ResearchVitamin D receptorFOXP3 geneT cellsHuman CD4Dihyroxyvitamin D3Retinoid X receptorCNS regionsPresence of VDRFoxp3 promoter activityHuman FOXP3 geneImmune regulatory effectsFoxp3 gene expressionFOXP3 gene promoterBinding of VDRD receptorCD4X receptorPromoter activityResponse element siteRegulatory effectsVDREPutative response elementsReceptorsD3Response element