Vulnerability of cholecystokinin-expressing GABAergic interneurons in the unilateral intrahippocampal kainate mouse model of temporal lobe epilepsy
Kang YJ, Clement EM, Park IH, Greenfield LJ, Smith BN, Lee SH. Vulnerability of cholecystokinin-expressing GABAergic interneurons in the unilateral intrahippocampal kainate mouse model of temporal lobe epilepsy. Experimental Neurology 2021, 342: 113724. PMID: 33915166, PMCID: PMC8192495, DOI: 10.1016/j.expneurol.2021.113724.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyIntrahippocampal kainate mouse modelVentral CA1 regionEpileptic miceCA1 pyramidal cellsSclerotic hippocampusPyramidal cellsSham controlsSpontaneous seizuresLobe epilepsyCA1 regionMouse modelFrequency of IPSCsNetwork oscillationsRecurrent spontaneous seizuresNumber of boutonsHippocampal theta oscillationsIpsilateral hippocampusElectrical recordingsVentral hippocampusCA1 layerGABAergic interneuronsStratum pyramidaleDorsal hippocampusBehavioral comorbidities