2017
Enhanced Therapeutic and Long-Term Dynamic Vascularization Effects of Human Pluripotent Stem Cell–Derived Endothelial Cells Encapsulated in a Nanomatrix Gel
Lee SJ, Sohn YD, Andukuri A, Kim S, Byun J, Han JW, Park IH, Jun HW, Yoon YS. Enhanced Therapeutic and Long-Term Dynamic Vascularization Effects of Human Pluripotent Stem Cell–Derived Endothelial Cells Encapsulated in a Nanomatrix Gel. Circulation 2017, 136: 1939-1954. PMID: 28972000, PMCID: PMC5685906, DOI: 10.1161/circulationaha.116.026329.Peer-Reviewed Original ResearchConceptsCell survivalHPSC-ECsHuman pluripotent stem cell-derived endothelial cellsEndothelial lineage differentiationGlycogen synthase kinase-3β inhibitorHuman pluripotent stem cellsStem cell-derived endothelial cellsGrowth factorDifferentiation of hPSCsLonger cell survivalEndothelial cellsCell-derived endothelial cellsVessel formationPluripotent stem cell-derived endothelial cellsBetter perfusion recoveryPluripotent stem cellsNanomatrix gelLong-term cell survivalMesodermal lineagesLineage differentiationHuman umbilical vein endothelial cellsUmbilical vein endothelial cellsDifferentiation systemFibroblast growth factorBasic fibroblast growth factor
2008
Patient-Specific Induced Pluripotent Stem Cells in Hurler Syndrome
Tolar J, Park I, Xia L, Osborn M, McElmurry R, Orchard P, Daley G, Blazar B. Patient-Specific Induced Pluripotent Stem Cells in Hurler Syndrome. Blood 2008, 112: 386. DOI: 10.1182/blood.v112.11.386.386.Peer-Reviewed Original ResearchGreen fluorescent proteinPluripotent stem cellsIPS cellsStem cellsMesenchymal stromal cellsTumor rejection antigen-1Such induced pluripotent stem cellsWild-type levelsAutologous pluripotent cellsTransient mRNA expressionInduced pluripotent stem cellsMouse embryo fibroblastsStage-specific embryonic antigen-3Adult stem cellsEmbryonic stem cell isolationHematopoietic progenyHematopoietic stem cellsStable transgenesisTransposon insertionMesodermal lineagesNumerous tissue typesSleeping Beauty transposon systemTranscription factorsNon-viral Sleeping Beauty (SB) transposon systemPluripotent cells