Intracerebral Transplants of GMP-Grade Human Umbilical Cord-Derived Mesenchymal Stromal Cells Effectively Treat Subacute-Phase Ischemic Stroke in a Rodent Model
Noh JE, Oh SH, Park IH, Song J. Intracerebral Transplants of GMP-Grade Human Umbilical Cord-Derived Mesenchymal Stromal Cells Effectively Treat Subacute-Phase Ischemic Stroke in a Rodent Model. Frontiers In Cellular Neuroscience 2020, 14: 546659. PMID: 33100972, PMCID: PMC7546889, DOI: 10.3389/fncel.2020.546659.Peer-Reviewed Original ResearchHuman umbilical cord-derived mesenchymal stromal cellsMiddle cerebral artery occlusionMesenchymal stromal cellsSubacute phaseRodent modelsUmbilical cord-derived mesenchymal stromal cellsStromal cellsIschemic penumbra regionCerebral artery occlusionGlial scar formationDelivery modeSame time pointsHuman umbilical cordStem cell therapyCandidate cell typesInfarct volumeArtery occlusionIschemic strokeIntracerebral transplantsTransplanted ratsCell-based therapiesChronic phaseFunctional recoveryTherapeutic effectBehavioral deficitsImplantation of the clinical‐grade human neural stem cell line, CTX0E03, rescues the behavioral and pathological deficits in the quinolinic acid‐lesioned rodent model of Huntington's disease
Yoon Y, Kim HS, Jeon I, Noh J, Park HJ, Lee S, Park I, Stevanato L, Hicks C, Corteling R, Barker RA, Sinden JD, Song J. Implantation of the clinical‐grade human neural stem cell line, CTX0E03, rescues the behavioral and pathological deficits in the quinolinic acid‐lesioned rodent model of Huntington's disease. Stem Cells 2020, 38: 936-947. PMID: 32374064, PMCID: PMC7496241, DOI: 10.1002/stem.3191.Peer-Reviewed Original ResearchConceptsMedium spiny neuronsNeural stem cell lineHuntington's diseaseQuinolinic acid (QA) lesion rat modelChronic ischemic stroke patientsStriatal medium spiny neuronsCell linesImmortalized neural stem cell linesIschemic stroke patientsDisease-modifying therapiesSignals of efficacyGlial scar formationHost brain tissueHuman neural stem cell lineSignificant behavioral improvementAutosomal dominant neurodegenerative diseaseCTX0E03 cellsEndogenous neurogenesisBDNF expressionGABAergic neuronsHD patientsStroke patientsFluoro-GoldRetrograde labelSpiny neurons