Featured Publications
Invasive Pneumococcal Disease After 2 Decades of Pneumococcal Conjugate Vaccine Use.
Yildirim I, Lapidot R, Shaik-Dasthagirisaheb Y, Hinderstein S, Lee H, Klevens M, Grant L, Arguedas Mohs A, Cane A, Madoff L, Johnson H, Ivanof C, Burns M, Pelton S. Invasive Pneumococcal Disease After 2 Decades of Pneumococcal Conjugate Vaccine Use. Pediatrics 2023, 153 PMID: 38087952, DOI: 10.1542/peds.2023-063039.Peer-Reviewed Original ResearchMeSH KeywordsChildHeptavalent Pneumococcal Conjugate VaccineHumansIncidenceInfantPneumococcal InfectionsPneumococcal VaccinesSerogroupStreptococcus pneumoniaeVaccines, ConjugateConceptsInvasive pneumococcal diseaseIPD casesPCV13 eraPneumococcal diseaseCases of IPDIncidence of IPDRates of IPDPneumococcal conjugate vaccine useSerotype 15B/CImplementation of PCV13Non-PCV13 serotypesPneumococcal conjugate vaccineConfidence intervalsStatewide surveillance systemIPD incidence ratesIPD ratesPenicillin nonsusceptibilityConjugate vaccineVaccine serotypesSerotype 19ASterile sitesIncidence rateVaccine useLower incidenceVaccine formulations
2020
Recognition and Outcomes of Pneumococcal Meningitis in 2 Tertiary Pediatric Hospitals Since the Introduction of the 13-Valent Pneumococcal Conjugate Vaccine
Stevens JP, Lively A, Jerris R, Yildirim I, Lantis P. Recognition and Outcomes of Pneumococcal Meningitis in 2 Tertiary Pediatric Hospitals Since the Introduction of the 13-Valent Pneumococcal Conjugate Vaccine. Pediatric Emergency Care 2020, 38: e354-e359. PMID: 33181795, DOI: 10.1097/pec.0000000000002288.Peer-Reviewed Original ResearchConceptsPneumococcal conjugate vaccineLumbar puncturePneumococcal meningitisConjugate vaccineMeningeal signsLow suspicionMental statusPositive cerebrospinal fluid culturesLonger hospital lengthStreptococcus pneumoniae meningitisCerebrospinal fluid culturesCranial nerve palsyHours of admissionTertiary pediatric hospitalPoor clinical outcomeTertiary healthcare systemPneumococcal meningitis casesPneumococcal immunizationPneumoniae meningitisHospital lengthNerve palsyPrimary outcomeAntibiotic administrationClinical outcomesPediatric hospital
2018
The relative invasive disease potential of Streptococcus pneumoniae among children after PCV introduction: A systematic review and meta-analysis
Balsells E, Dagan R, Yildirim I, Gounder PP, Steens A, Muñoz-Almagro C, Mameli C, Kandasamy R, Lavi N, Daprai L, van der Ende A, Trzciński K, Nzenze SA, Meiring S, Foster D, Bulkow LR, Rudolph K, Valero-Rello A, Ducker S, Vestrheim DF, von Gottberg A, Pelton SI, Zuccotti G, Pollard AJ, Sanders EAM, Campbell H, Madhi SA, Nair H, Kyaw MH. The relative invasive disease potential of Streptococcus pneumoniae among children after PCV introduction: A systematic review and meta-analysis. Journal Of Infection 2018, 77: 368-378. PMID: 29964140, DOI: 10.1016/j.jinf.2018.06.004.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal diseaseInvasive disease potentialPneumococcal conjugate vaccineNon-vaccine typesPCV introductionPneumococcal diseaseClinical syndromePneumococcal serotypesSurveillance of IPDDisease potentialSystematic reviewCurrent pneumococcal conjugate vaccinesYears of ageRandom-effects modelConjugate vaccineRoutine immunisationDisease presentationFuture vaccinesStreptococcus pneumoniaeSerotype 1SerotypesSyndromeCarriageChildrenVaccine
2017
Surveillance of pneumococcal colonization and invasive pneumococcal disease reveals shift in prevalent carriage serotypes in Massachusetts’ children to relatively low invasiveness
Yildirim I, Little BA, Finkelstein J, Lee G, Hanage WP, Shea K, Pelton SI, T, Health H. Surveillance of pneumococcal colonization and invasive pneumococcal disease reveals shift in prevalent carriage serotypes in Massachusetts’ children to relatively low invasiveness. Vaccine 2017, 35: 4002-4009. PMID: 28645717, DOI: 10.1016/j.vaccine.2017.05.077.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal diseasePneumococcal conjugate vaccineInvasive disease potentialPneumococcal diseaseLow invasive capacityInvasive capacityPCV13 eraCommon serotypesIncidence of IPDNasopharyngeal colonization ratePost-vaccine eraDisease potentialCarriage serotypesPCV eraConjugate vaccineNasopharyngeal carriageCarriage prevalencePneumococcal colonizationEnhanced surveillanceDynamic epidemiologyAge groupsSerotype 3Serotype XOlder childrenLow invasiveness
2015
Vaccination, Underlying Comorbidities, and Risk of Invasive Pneumococcal Disease
Yildirim I, Shea KM, Little BA, Silverio AL, Pelton SI. Vaccination, Underlying Comorbidities, and Risk of Invasive Pneumococcal Disease. Pediatrics 2015, 135: 495-503. PMID: 25647674, DOI: 10.1542/peds.2014-2426.Peer-Reviewed Original ResearchMeSH KeywordsBacterial CapsulesChildChild, PreschoolComorbidityFemaleFollow-Up StudiesHumansIncidenceInfantMaleMassachusettsPneumococcal InfectionsPneumococcal VaccinesPopulation SurveillancePrognosisRetrospective StudiesRisk AssessmentRisk FactorsStreptococcus pneumoniaeVaccinationVaccines, ConjugateConceptsInvasive pneumococcal diseasePneumococcal diseaseUnderlying conditionOutcomes of IPDPrevention of IPDChildhood invasive pneumococcal diseasePneumococcal vaccination statusPolysaccharide pneumococcal vaccineYear of diagnosisPrimary care providersCase fatality rateChronic respiratory diseasesImmunocompromising conditionsIPD diagnosisUnderlying comorbiditiesImmunization PracticesIPD casesPneumococcal vaccineVaccination statusConjugate vaccineMassachusetts childrenClinical presentationSerotype distributionHigher hospitalizationClinical data
2012
Evolving Picture of Invasive Pneumococcal Disease in Massachusetts Children
Yildirim I, Stevenson A, Hsu KK, Pelton SI. Evolving Picture of Invasive Pneumococcal Disease in Massachusetts Children. The Pediatric Infectious Disease Journal 2012, 31: 1016-1021. PMID: 22673142, DOI: 10.1097/inf.0b013e3182615615.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnti-Bacterial AgentsChildChild, PreschoolCluster AnalysisFemaleHeptavalent Pneumococcal Conjugate VaccineHumansIncidenceInfantMaleMassachusettsMeningitis, PneumococcalMicrobial Sensitivity TestsMultilocus Sequence TypingPneumococcal VaccinesProspective StudiesSepsisSerotypingStreptococcus pneumoniaeConceptsInvasive pneumococcal diseasePneumococcal conjugate vaccine serotypesPneumococcal conjugate vaccineIPD incidence ratesMassachusetts childrenPCV7 eraIPD casesPneumococcal diseaseConjugate vaccineVaccine serotypesSerotype 19AIncidence rateCases of IPDChildhood invasive pneumococcal diseaseHeptavalent pneumococcal conjugate vaccinePopulation-based surveillanceOverall IPD incidence ratesCeftriaxone-resistant isolatesYears of ageAntimicrobial susceptibility testingBacteremic pneumoniaPCV7 serotypesMultilocus sequence typingNonvaccine serotypesClinical presentation
2010
Serotype specific invasive capacity and persistent reduction in invasive pneumococcal disease
Yildirim I, Hanage WP, Lipsitch M, Shea KM, Stevenson A, Finkelstein J, Huang SS, Lee GM, Kleinman K, Pelton SI. Serotype specific invasive capacity and persistent reduction in invasive pneumococcal disease. Vaccine 2010, 29: 283-288. PMID: 21029807, PMCID: PMC3139683, DOI: 10.1016/j.vaccine.2010.10.032.Peer-Reviewed Original ResearchMeSH KeywordsCarrier StateChildChild, PreschoolHumansIncidenceInfantInfant, NewbornMassachusettsPneumococcal InfectionsSerotypingStreptococcus pneumoniaeConceptsInvasive pneumococcal diseaseInvasive capacityPneumococcal diseaseIncidence of IPDNew pneumococcal conjugate vaccinesPneumococcal conjugate vaccineSterile body sitesStreptococcus pneumoniae serotypesCarriage serotypesNasopharyngeal acquisitionNP carriagePCV eraReplacement serotypesIPD incidenceRespiratory seasonsConjugate vaccineMassachusetts childrenCarriage prevalenceCommon serotypesPneumoniae serotypesOngoing surveillanceEnhanced surveillanceBody sitesPersistent reductionSerotype XPneumococcal serotypes causing pediatric meningitis in Turkey: application of a new technology in the investigation of cases negative by conventional culture
Ceyhan M, Yildirim I, Sheppard C, George R. Pneumococcal serotypes causing pediatric meningitis in Turkey: application of a new technology in the investigation of cases negative by conventional culture. European Journal Of Clinical Microbiology & Infectious Diseases 2010, 29: 289-293. PMID: 20087750, DOI: 10.1007/s10096-009-0853-y.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal diseasePolymerase chain reactionPneumococcal diseasePneumococcal serotypesCSF samplesAntigen detectionSurveillance of serotypesPneumococcal conjugate vaccinePrior antibiotic useSerotypes/groupsCerebrospinal fluid samplesYears of agePediatric meningitisBacterial meningitisVaccine impactConjugate vaccineActive surveillanceAntibiotic useCommon serotypesQuellung reactionStreptococcus pneumoniaeAge groupsInvestigation of casesSerotype 5Ply gene
2008
A Prospective Study of Etiology of Childhood Acute Bacterial Meningitis, Turkey - Volume 14, Number 7—July 2008 - Emerging Infectious Diseases journal - CDC
Ceyhan M, Yildirim I, Balmer P, Borrow R, Dikici B, Turgut M, Kurt N, Aydogan A, Ecevit C, Anlar Y, Gulumser O, Tanir G, Salman N, Gurler N, Hatipoglu N, Hacimustafaoglu M, Celebi S, Coskun Y, Alhan E, Celik U, Camcioglu Y, Secmeer G, Gur D, Gray S. A Prospective Study of Etiology of Childhood Acute Bacterial Meningitis, Turkey - Volume 14, Number 7—July 2008 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2008, 14: 1089-1096. PMID: 18598630, PMCID: PMC2600347, DOI: 10.3201/eid1407.070938.Peer-Reviewed Original ResearchConceptsAcute bacterial meningitisBacterial meningitisSerogroup WCSF samplesChildhood acute bacterial meningitisHaemophilus influenzae type bInfectious Diseases journal - CDCEtiology of meningitisInfluenzae type bCerebrospinal fluid samplesPCR-positive samplesProspective studyBacterial etiologyMeningococcal diseaseVaccination policyCost of diseaseMeningitisS. pneumoniaeStreptococcus pneumoniaeClinical diagnosisEtiologyN. meningitidisNeisseria meningitidisDiseaseType B