2021
Impact of circulating SARS-CoV-2 variants on mRNA vaccine-induced immunity
Lucas C, Vogels CBF, Yildirim I, Rothman JE, Lu P, Monteiro V, Gehlhausen JR, Campbell M, Silva J, Tabachnikova A, Peña-Hernandez MA, Muenker MC, Breban MI, Fauver JR, Mohanty S, Huang J, Shaw A, Ko A, Omer S, Grubaugh N, Iwasaki A. Impact of circulating SARS-CoV-2 variants on mRNA vaccine-induced immunity. Nature 2021, 600: 523-529. PMID: 34634791, PMCID: PMC9348899, DOI: 10.1038/s41586-021-04085-y.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 variantsMRNA vaccine-induced immunityT-cell activation markersSARS-CoV-2 antibodiesSecond vaccine doseVaccine-induced immunityCell activation markersT cell responsesHigh antibody titresSARS-CoV-2Vaccine boosterVaccine doseActivation markersVaccine dosesHumoral immunityAntibody titresMRNA vaccinesVitro stimulationNeutralization capacityNeutralization responseCell responsesE484KNucleocapsid peptideAntibody-binding sitesGreater reduction
2020
Plasmablast, Memory B Cell, CD4+ T Cell, and Circulating Follicular Helper T Cell Responses to a Non-Replicating Modified Vaccinia Ankara Vaccine
Anderson EJ, Lai L, Wrammert J, Kabbani S, Xu Y, Priyamvada L, Hill H, Goll JB, Jensen TL, Kao C, Yildirim I, Rouphael N, Jackson L, Mulligan MJ. Plasmablast, Memory B Cell, CD4+ T Cell, and Circulating Follicular Helper T Cell Responses to a Non-Replicating Modified Vaccinia Ankara Vaccine. Vaccines 2020, 8: 69. PMID: 32041104, PMCID: PMC7158692, DOI: 10.3390/vaccines8010069.Peer-Reviewed Original ResearchMemory B cellsPlaque reduction neutralization testVaccinia Ankara vaccineCD4 T cellsT cellsB cellsDay 1Follicular helper T cell responsesIgG-secreting B cellsModified Vaccinia Ankara VaccineFollicular helper T cellsHelper T cell responsesVaccinia-specific antibodiesT cell responsesHelper T cellsReduction neutralization testEnzyme-linked immunosorbentSecond vaccineEvaluable specimensInjection recipientsPRNT titersDay 29Neutralization testPlasmablastsNovel vaccines