Featured Publications
Patient‐detectable responsive neurostimulation as a seizure warning system
Quraishi IH, Hirsch LJ. Patient‐detectable responsive neurostimulation as a seizure warning system. Epilepsia 2021, 62: e110-e116. PMID: 34018182, PMCID: PMC8629031, DOI: 10.1111/epi.16933.Peer-Reviewed Original ResearchConceptsResponsive neurostimulation systemFocal impaired awareness seizuresProportion of patientsQuality of lifeSeizure warningTolerable symptomsClinical seizuresLatter therapySelect patientsAwareness seizuresEpileptiform activityEarly recognitionResponsive neurostimulationEpileptiform patternsCognitive impairmentPatientsNeurostimulation systemSymptomsSeizuresTherapyTreatment of clustersStimulationSeizure warning systemSeizure recognitionEpilepsy
2024
Multifocal Epilepsy and Non-dominant Cingulate Lesion
Herlopian A, Gray T, Quraishi I. Multifocal Epilepsy and Non-dominant Cingulate Lesion. 2024, 393-429. DOI: 10.1007/978-3-031-23828-4_18.ChaptersMultifocal epilepsyEEG findings of patientsFindings of patientsAnti-seizure medicationsPrognostic roleSurgical outcomesEEG findingsEEG changesCingulate epilepsyHabitual seizuresIctal tachycardiaAnterior cingulate gyrusEpilepsy monitoring unitVascular lesionsIctal speechPredictive valueOutcome determinantsPatientsMonitor unitsCingulate cortexEpilepsyCingulate gyrusCingulateCortexEEGSystematic 1 Hz direct electrical stimulation for seizure induction: A reliable method for localizing seizure onset zone and predicting seizure freedom
Sivaraju A, Quraishi I, Collins E, McGrath H, Ramos A, Turk-Browne N, Zaveri H, Damisah E, Spencer D, Hirsch L. Systematic 1 Hz direct electrical stimulation for seizure induction: A reliable method for localizing seizure onset zone and predicting seizure freedom. Brain Stimulation 2024, 17: 339-345. PMID: 38490472, DOI: 10.1016/j.brs.2024.03.011.Peer-Reviewed Original ResearchSeizure inductionSeizure onset zoneSurgical outcomesHabitual seizuresOnset zonePredicting seizure freedomExcellent surgical outcomesProspective cohort studyMann-Whitney testConsecutive patientsFisher's exactSeizure freedomRefractory epilepsyCohort studyPost-surgeryInsular regionsMann-WhitneyPatientsIntracranial EEGSeizuresLocalizing seizure onset zonesStimulationElectrical stimulationMedial temporal regionsTemporal regions
2023
Intracranial Entrainment Reveals Statistical Learning across Levels of Abstraction
Sherman B, Aljishi A, Graves K, Quraishi I, Sivaraju A, Damisah E, Turk-Browne N. Intracranial Entrainment Reveals Statistical Learning across Levels of Abstraction. Journal Of Cognitive Neuroscience 2023, 35: 1312-1328. PMID: 37262357, DOI: 10.1162/jocn_a_02012.Peer-Reviewed Original ResearchIctal Thalamic Recordings in Patients with Deep Brain Stimulation Targeting Thalamic NucleiIdentify whether ictal thalamic EEG signals could be derived from ambulatory recordings in patients with pharmacoresistant epilepsy treated with deep brain stimulation (DBS) targeting either bilateral anterior thalamic nuclei (ATN) or centromedian nuclei (CMN). (P5-1.008)
Saab L, Jiang J, Quraishi I, Herlopian A. Ictal Thalamic Recordings in Patients with Deep Brain Stimulation Targeting Thalamic NucleiIdentify whether ictal thalamic EEG signals could be derived from ambulatory recordings in patients with pharmacoresistant epilepsy treated with deep brain stimulation (DBS) targeting either bilateral anterior thalamic nuclei (ATN) or centromedian nuclei (CMN). (P5-1.008). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000204225.Peer-Reviewed Original Research
2022
Evaluating consciousness and awareness during focal seizures: responsiveness testing versus recall testing
Ramirez V, Litvinov B, Gunawardane NA, Zhao CW, Yotter C, Quraishi IH, Blumenfeld H. Evaluating consciousness and awareness during focal seizures: responsiveness testing versus recall testing. Epileptic Disorders 2022, 24: 899-905. PMID: 35904040, PMCID: PMC10042123, DOI: 10.1684/epd.2022.1472.Peer-Reviewed Original ResearchConceptsFocal seizuresResponsiveness testingCurrent International LeagueClinical practice settingEEG-video monitoringEpilepsy monitoring unitImportant clinical settingsEpilepsy guidelinesPatient groupFocal epilepsyIctal eventsClinical careInternational LeagueSeizuresPatientsClinical settingPractice settingsClassification guidelinesFurther studiesEpilepsyResponsivenessRecall of experiencesPreliminary findingsRecall testingSettingHippocampal recording via the RNS system reveals marked ipsilateral activation of epileptiform activity during Wada testing
Quraishi IH, Brown FC, Johnson MH, Hirsch LJ. Hippocampal recording via the RNS system reveals marked ipsilateral activation of epileptiform activity during Wada testing. Epilepsy & Behavior 2022, 134: 108854. PMID: 35905518, DOI: 10.1016/j.yebeh.2022.108854.Peer-Reviewed Original ResearchConceptsResponsive neurostimulation systemWada testingEpileptiform activityElicitation of seizuresTemporal lobe resectionInternal carotid arteryMedial temporal structuresHippocampal vasculatureIpsilateral activationLobe resectionPosterior circulationElectrographic seizuresTemporal lobectomyElectrographic changesIntractable epilepsyClinical correlatesWada testCarotid arteryHippocampal spikesNegative findingsNeurostimulation systemHippocampal EEGHippocampal activityPatientsTransient increase
2021
Miglustat Therapy for SCARB2-Associated Action Myoclonus–Renal Failure Syndrome
Quraishi IH, Szekely AM, Shirali AC, Mistry PK, Hirsch LJ. Miglustat Therapy for SCARB2-Associated Action Myoclonus–Renal Failure Syndrome. Neurology Genetics 2021, 7: e614. PMID: 34337151, PMCID: PMC8320328, DOI: 10.1212/nxg.0000000000000614.Peer-Reviewed Original ResearchAction myoclonus-renal failure syndromeNeurologic symptomsAction myoclonusFailure syndromeProgressive myoclonic epilepsySubstrate reduction therapyWhole-exome sequencingMiglustat therapyAvailable medicationsEarly mortalityReduction therapyMyoclonic epilepsySteady worseningGaucher diseaseMyoclonusGlycosphingolipid metabolismExome sequencingGene mutationsGlucosylceramide accumulationPatientsSeizuresMiglustatSyndromeTherapySymptomsElectrical cortical stimulation can impair production of the alphabet without impairing counting
Rojas PH, Sivaraju A, Quraishi IH, Vanderlind M, Rofes A, Połczynska-Bletsos MM, Spencer DD, Hirsch LJ, Benjamin CFA. Electrical cortical stimulation can impair production of the alphabet without impairing counting. Epilepsy & Behavior Reports 2021, 15: 100433. PMID: 33778464, PMCID: PMC7985277, DOI: 10.1016/j.ebr.2021.100433.Peer-Reviewed Case Reports and Technical NotesElectrical stimulation mappingCortical electrical stimulation mappingDrug-resistant focal epilepsyPatient experienced lossDrug-resistant epilepsyElectrical cortical stimulationLanguage-dominant hemisphereSuperior temporal gyrusPosterior superior temporal gyrusCortical stimulationFocal epilepsyStimulation mappingDominant hemispherePatientsTemporal gyrusSelective impairmentLanguage functionEpilepsyExperienced lossImpairmentBrainRiskLanguage impairmentSurgerySole means
2016
Hypothermia associated with clobazam use in adult epilepsy
Gauthier AC, Quraishi IH, Mattson RH. Hypothermia associated with clobazam use in adult epilepsy. Epilepsy & Behavior Reports 2016, 5: 17-18. PMID: 26870662, PMCID: PMC4739151, DOI: 10.1016/j.ebcr.2016.01.002.Peer-Reviewed Case Reports and Technical NotesClobazam useEvidence of infectionThyroid-stimulating hormoneEpisodes of hypothermiaAvoidable emergency departmentAdult patientsAdult epilepsyPediatric patientsEmergency departmentCase reportEarly recognitionMore episodesTotal episodesCortisol levelsHypothermiaPatientsClobazamEpilepsyFirst caseEpisodesMonthsMost instancesCouple monthsDiscontinuationHospitalization