2019
Neural computations of threat in the aftermath of combat trauma
Homan P, Levy I, Feltham E, Gordon C, Hu J, Li J, Pietrzak RH, Southwick S, Krystal JH, Harpaz-Rotem I, Schiller D. Neural computations of threat in the aftermath of combat trauma. Nature Neuroscience 2019, 22: 470-476. PMID: 30664770, PMCID: PMC6829910, DOI: 10.1038/s41593-018-0315-x.Peer-Reviewed Original ResearchConceptsPTSD symptomsPost-traumatic stress disorder symptomsHigher PTSD symptom severityThreat-predictive cuesPTSD symptom severityAssociative threatPredictive cuesNeural trackingDisorder symptomsPrediction errorCombat veteransDynamic learning rateNegative outcomesCombat traumaSmaller amygdala volumesNeural computationLatent markersSymptomatic veteransSymptom severityAmygdala volumeAssociabilityCuesLearning rateVeteransSymptoms
2018
Locus of control in US combat veterans: Unique associations with posttraumatic stress disorder 5-factor model symptom clusters
Smith NB, Sippel LM, Presseau C, Rozek D, Mota N, Gordon C, Horvath M, Harpaz-Rotem I. Locus of control in US combat veterans: Unique associations with posttraumatic stress disorder 5-factor model symptom clusters. Psychiatry Research 2018, 268: 152-156. PMID: 30029062, DOI: 10.1016/j.psychres.2018.07.015.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderLocus of controlPTSD symptom clustersOverall PTSD symptomsAvoidance symptomsPTSD symptomsSymptom clustersStress disorderCombat veteransExternal locusCombat exposureCorrelates of PTSDSpecific PTSD symptom clustersTrauma-focused treatmentSelf-report measuresUS combat veteransIntervention effortsUnique associationUS military veteransExtreme scoresPotential correlatesMilitary veteransBivariate correlationsOnly avoidanceSignificant correlates
2014
Diffusion of Prazosin Treatment for PTSD
Hermes E, Harpaz-Rotem I, Rosenheck R. Diffusion of Prazosin Treatment for PTSD. American Journal Of Psychiatry 2014, 171: 117-117. PMID: 24399430, DOI: 10.1176/appi.ajp.2013.13091259.Peer-Reviewed Original Research
2012
Examining the relation between combat-related concussion, a novel 5-factor model of posttraumatic stress symptoms, and health-related quality of life in Iraq and Afghanistan veterans.
Tsai J, Whealin JM, Scott JC, Harpaz-Rotem I, Pietrzak RH. Examining the relation between combat-related concussion, a novel 5-factor model of posttraumatic stress symptoms, and health-related quality of life in Iraq and Afghanistan veterans. The Journal Of Clinical Psychiatry 2012, 73: 1110-8. PMID: 22781019, DOI: 10.4088/jcp.11m07587.Peer-Reviewed Original ResearchConceptsMental health-related qualityHealth-related qualityPersistent postconcussive symptomsCombat-related concussionPostconcussive symptomsAlcohol use problemsPTSD symptomsAfghanistan veteransPhysical health-related qualityForm Health SurveyDysphoric arousal symptomsUse problemsIraq/Afghanistan veteransStrongest predictorPosttraumatic stress disorder (PTSD) symptomsClinical characteristicsProgram registryHealth SurveyPsychiatric cliniciansPosttraumatic stress symptomsMultivariate analysisSymptomsConcussionBivariate analysisSymptomatic veterans
2009
Tracing the Flow of Knowledge: Geographic Variability in the Diffusion of Prazosin Use for the Treatment of Posttraumatic Stress Disorder Nationally in the Department of Veterans Affairs
Harpaz-Rotem I, Rosenheck RA. Tracing the Flow of Knowledge: Geographic Variability in the Diffusion of Prazosin Use for the Treatment of Posttraumatic Stress Disorder Nationally in the Department of Veterans Affairs. JAMA Psychiatry 2009, 66: 417-421. PMID: 19349311, DOI: 10.1001/archgenpsychiatry.2008.536.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderHealth care systemVeterans AffairsStress disorderSound Health Care SystemCare systemUse of prazosinPercentage of patientsTreatment of patientsTreatment of nightmaresPrazosin usePatient characteristicsNational health care systemMedical CenterMAIN OUTCOMEPrazosinPassive disseminationPatientsClinical practiceNew treatmentsPassive diffusionPrazosin hydrochlorideFiscal year 2004TreatmentPreliminary evidence