2019
Posttraumatic Stress Disorder Symptoms, Functioning, and Suicidal Ideation in US Military Veterans: A Symptomics Approach.
Kachadourian LK, Harpaz-Rotem I, Tsai J, Southwick SM, Pietrzak RH. Posttraumatic Stress Disorder Symptoms, Functioning, and Suicidal Ideation in US Military Veterans: A Symptomics Approach. The Primary Care Companion For CNS Disorders 2019, 21 PMID: 31050228, DOI: 10.4088/pcc.18m02402.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderPositive affectMeasures of functioningCognitive functioningNegative thoughtsPTSD symptomsConcentration difficultiesSleep difficultiesTreatment of PTSDUS military veteransSeverity of PTSDPosttraumatic stress disorder (PTSD) symptomsSuicidal ideationDSM-5 PTSD symptomsMilitary veteransLifetime trauma burdenIrritability/aggressionHyperarousal symptomsDisorder symptomsStress disorderPsychogenic amnesiaPTSD diagnosisQuality of lifeMental functioningMost variance
2017
Synaptic Loss and the Pathophysiology of PTSD: Implications for Ketamine as a Prototype Novel Therapeutic
Krystal JH, Abdallah CG, Averill LA, Kelmendi B, Harpaz-Rotem I, Sanacora G, Southwick SM, Duman RS. Synaptic Loss and the Pathophysiology of PTSD: Implications for Ketamine as a Prototype Novel Therapeutic. Current Psychiatry Reports 2017, 19: 74. PMID: 28844076, PMCID: PMC5904792, DOI: 10.1007/s11920-017-0829-z.Peer-Reviewed Original ResearchConceptsSynaptic connectivityRapid-acting treatmentPathophysiology of PTSDPotential clinical importanceTreatment of PTSDSynaptic lossPurpose of ReviewStudiesDisconnection syndromeClinical importanceNovel pharmacotherapeuticsNovel therapeuticsPTSD symptomsRecent FindingsHerePTSDPathophysiologyKetamineTreatmentDisordersTherapeutic applicationsStress-related lossesSyndromeSymptomsPharmacotherapeutics
2013
Latent class analysis of personality disorders in adults with posttraumatic stress disorder: results from the National Epidemiologic Survey on Alcohol and Related Conditions.
Tsai J, Harpaz-Rotem I, Pilver CE, Wolf EJ, Hoff RA, Levy KN, Sareen J, Pietrzak RH. Latent class analysis of personality disorders in adults with posttraumatic stress disorder: results from the National Epidemiologic Survey on Alcohol and Related Conditions. The Journal Of Clinical Psychiatry 2013, 75: 276-84. PMID: 24345427, DOI: 10.4088/jcp.13m08466.Peer-Reviewed Original ResearchConceptsHealth-related qualityMental health-related qualityPosttraumatic stress disorderDSM-IV personality disordersNational Epidemiologic SurveyPersonality disorderDisorder classesEpidemiologic SurveyLower mental health-related qualityRelated conditionsComorbid Axis I disordersStress disorderTreatment of PTSDPTSD symptomsComorbid Axis I diagnosesAxis I comorbidityLatent class analysisCo-occurring personality disordersAxis I diagnosisAxis I DisordersTreatment characteristicsI disordersUS adultsLifetime diagnosisTreatment approaches
2008
Pharmacologic Treatment of Posttraumatic Stress Disorder Among Privately Insured Americans
Harpaz-Rotem I, Rosenheck RA, Mohamed S, Desai RA. Pharmacologic Treatment of Posttraumatic Stress Disorder Among Privately Insured Americans. Psychiatric Services 2008, 59: 1184-1190. PMID: 18832505, DOI: 10.1176/ps.2008.59.10.1184.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderPsychotropic medicationsMedication classesStress disorderTreatment of PTSDMental health care usersSymptom-specific responsesComorbid psychiatric disordersUse of anxiolyticsMultivariate logistic regressionDiagnosis of PTSDMajor depressive disorderMental health servicesHealth care usersMedication usePharmacologic treatmentAntidepressant useHealth insurance plansMarketScan databaseAntipsychotic usePrivate health insurance plansPharmacological treatmentDepressive disorderSpecific symptomsMillions of Americans