2023
Characterization of Mental Health in US Veterans Before, During, and 2 Years After the Onset of the COVID-19 Pandemic
Fischer I, Na P, Harpaz-Rotem I, Krystal J, Pietrzak R. Characterization of Mental Health in US Veterans Before, During, and 2 Years After the Onset of the COVID-19 Pandemic. JAMA Network Open 2023, 6: e230463. PMID: 36821116, PMCID: PMC9951035, DOI: 10.1001/jamanetworkopen.2023.0463.Peer-Reviewed Original ResearchConceptsUS veteransRates of anxietyCOVID-19 pandemicCohort studyDepressive disorderMental healthVeteransPandemic
2022
Distinguishing emotional numbing symptoms of posttraumatic stress disorder from major depressive disorder
Duek O, Seidemann R, Pietrzak R, Harpaz-Rotem I. Distinguishing emotional numbing symptoms of posttraumatic stress disorder from major depressive disorder. Journal Of Affective Disorders 2022, 324: 294-299. PMID: 36586605, DOI: 10.1016/j.jad.2022.12.105.Peer-Reviewed Original ResearchConceptsEmotional numbing symptomsPosttraumatic stress disorderNumbing symptomsEmotional numbingStress disorderSymptom clustersTrauma-exposed individualsGreater PTSD severityMajor depressive disorderContext of traumaUnique variancePTSD symptomsPTSD phenotypePTSD severityDifferent symptom clustersWorse treatment outcomesDepressive disorderCore aspectsNumbingDistinct contributionsMDD symptomsDSM-IIIFunctional impairmentDisordersTreatment outcomesMental Health Burden in Enlisted and Commissioned U.S. Military Veterans: Importance of Indirect Trauma Exposure in Commissioned Veterans
Merians AN, Na PJ, Tsai J, Harpaz-Rotem I, Pietrzak RH. Mental Health Burden in Enlisted and Commissioned U.S. Military Veterans: Importance of Indirect Trauma Exposure in Commissioned Veterans. Psychiatry 2022, 85: 418-432. PMID: 35532217, DOI: 10.1080/00332747.2022.2068301.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderMajor depressive disorderU.S. military veteransSuicidal ideationMilitary veteransTrauma exposureMost mental health outcomesMental health burdenPast-year suicidal ideationDrug use disordersU.S. veteran populationMental health historyHigh exposureMental health outcomesMultivariable analysisDepressive disorderNational HealthHealth burdenPost-stratification weightsUse disordersVeteran populationHealth historyHealth outcomesIndirect trauma exposureVeterans Study
2018
Protective correlates of suicidality among veterans with histories of posttraumatic stress disorder and major depressive disorder: Results from the National Health and Resilience in Veterans Study
Kachadourian LK, Tsai J, Harpaz-Rotem I, Southwick SM, Pietrzak RH. Protective correlates of suicidality among veterans with histories of posttraumatic stress disorder and major depressive disorder: Results from the National Health and Resilience in Veterans Study. Journal Of Affective Disorders 2018, 246: 731-737. PMID: 30616162, DOI: 10.1016/j.jad.2018.12.058.Peer-Reviewed Original ResearchMeSH KeywordsAdultCross-Sectional StudiesDepressive Disorder, MajorFemaleHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisOptimismPrevalenceProtective FactorsResilience, PsychologicalRisk FactorsStress Disorders, Post-TraumaticSuicidal IdeationSuicideSuicide, AttemptedSurveys and QuestionnairesUnited StatesVeteransYoung AdultConceptsMajor depressive disorderPosttraumatic stress disorderProtective correlatesSuicidal ideationSuicide attemptsProtective factorsDepressive disorderNational HealthVeterans StudyMultivariable logistic regression analysisSuicidal behaviorStress disorderHistory of PTSDLogistic regression analysisSample of veteransAssessment of suicidalityLifetime suicide attemptsRisk factorsHigh-risk sampleTreatment approachesU.S. veteransWeb-based surveyCross-sectional natureSuicide riskSelf-report items
2017
Oxytocin and Stress-related Disorders: Neurobiological Mechanisms and Treatment Opportunities
Sippel LM, Allington CE, Pietrzak RH, Harpaz-Rotem I, Mayes LC, Olff M. Oxytocin and Stress-related Disorders: Neurobiological Mechanisms and Treatment Opportunities. Chronic Stress 2017, 1: 2470547016687996. PMID: 28649672, PMCID: PMC5482285, DOI: 10.1177/2470547016687996.Peer-Reviewed Original ResearchStress-related disordersStress-related psychiatric disordersNeurobiological mechanismsPosttraumatic stress disorderCritical moderating variablePsychiatric disordersStress disorderNeurohormone oxytocinClinical populationsEndogenous oxytocinModerating variableHeterogeneous findingsHealthy samplesOverview of evidenceSingle-dose studyMajor depressive disorderPromising findingsOxytocinDisordersDepressive disorderDosing schedulesNovel pharmacotherapiesMultidose studyReliable biomarkersTreatment opportunities
2012
Psychotherapy use in a privately insured population of patients diagnosed with a mental disorder
Harpaz-Rotem I, Libby D, Rosenheck RA. Psychotherapy use in a privately insured population of patients diagnosed with a mental disorder. Social Psychiatry And Psychiatric Epidemiology 2012, 47: 1837-1844. PMID: 22349151, DOI: 10.1007/s00127-012-0486-9.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnxiety DisordersComorbidityDatabases as TopicDepressive Disorder, MajorFemaleHealth Care SurveysHumansInsurance CoverageInsurance, HealthLogistic ModelsMaleMental DisordersMental Health ServicesMiddle AgedPrivate SectorPsychotherapyStress Disorders, Post-TraumaticTreatment OutcomeUnited StatesConceptsMajor depressive disorderUse of psychotherapyPosttraumatic stress disorderReceipt of psychotherapyPsychotherapy visitsDepressive disorderMild depressionBipolar disorderMental disordersStress disorderAlcohol useCorrelates of receiptCurrent Procedural Terminology codesPopulation of patientsLarge claims databaseAlternative drug therapiesProcedural Terminology codesMental health servicesMultivariate binary regressionEffectiveness of psychotherapyPatient characteristicsClaims databasePharmacological treatmentDrug therapyPsychotherapy use
2008
Pharmacologic Treatment of Posttraumatic Stress Disorder Among Privately Insured Americans
Harpaz-Rotem I, Rosenheck RA, Mohamed S, Desai RA. Pharmacologic Treatment of Posttraumatic Stress Disorder Among Privately Insured Americans. Psychiatric Services 2008, 59: 1184-1190. PMID: 18832505, DOI: 10.1176/ps.2008.59.10.1184.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderPsychotropic medicationsMedication classesStress disorderTreatment of PTSDMental health care usersSymptom-specific responsesComorbid psychiatric disordersUse of anxiolyticsMultivariate logistic regressionDiagnosis of PTSDMajor depressive disorderMental health servicesHealth care usersMedication usePharmacologic treatmentAntidepressant useHealth insurance plansMarketScan databaseAntipsychotic usePrivate health insurance plansPharmacological treatmentDepressive disorderSpecific symptomsMillions of Americans
2004
Changes in Outpatient Psychiatric Diagnosis in Privately Insured Children and Adolescents from 1995 to 2000
Harpaz-Rotem I, Rosenheck RA. Changes in Outpatient Psychiatric Diagnosis in Privately Insured Children and Adolescents from 1995 to 2000. Child Psychiatry & Human Development 2004, 34: 329-340. PMID: 15039605, DOI: 10.1023/b:chud.0000020683.08514.2d.Peer-Reviewed Original ResearchConceptsOutpatient mental health servicesProportion of childrenMental health servicesSubstance abuse disordersMental health problemsHealth insurance plansPrivate health insurance plansDepressive disorderAbuse disordersPsychiatric diagnosisDiagnostic prevalenceBipolar disorderHealth problemsHealth servicesInsurance plansDiagnostic patternsDisordersChildrenYear periodAdolescentsPrevalenceDiagnosisYears 1995Dramatic increase