2023
Neural valuation of rewards and punishments in posttraumatic stress disorder: a computational approach
Jia R, Ruderman L, Pietrzak R, Gordon C, Ehrlich D, Horvath M, Mirchandani S, DeFontes C, Southwick S, Krystal J, Harpaz-Rotem I, Levy I. Neural valuation of rewards and punishments in posttraumatic stress disorder: a computational approach. Translational Psychiatry 2023, 13: 101. PMID: 36977676, PMCID: PMC10050320, DOI: 10.1038/s41398-023-02388-4.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderValuation systemStress disorderCombat veteransMaintenance of PTSDSubjective valueBrain valuation systemNeural valuation systemVentromedial prefrontal cortexFunctional MRI studyFunction of symptomsMale combat veteransNeural valuationSeries of choicesFear learningPunishment processingPosttrauma symptomsPTSD symptomsNeural encodingNeural mechanismsUncertain optionsPrefrontal cortexSubjective valuationVentral striatumMonetary gains
2019
Randomized Controlled Trial of Imagery Rehearsal for Posttraumatic Nightmares in Combat Veterans.
Harb GC, Cook JM, Phelps AJ, Gehrman PR, Forbes D, Localio R, Harpaz-Rotem I, Gur RC, Ross RJ. Randomized Controlled Trial of Imagery Rehearsal for Posttraumatic Nightmares in Combat Veterans. Journal Of Clinical Sleep Medicine 2019, 15: 757-767. PMID: 31053215, PMCID: PMC6510682, DOI: 10.5664/jcsm.7770.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyPosttraumatic stress disorderNightmare Distress QuestionnaireNightmare Frequency QuestionnaireBehavioral therapySevere posttraumatic stress disorderUnited States veteransOperation Enduring Freedom/Operation Iraqi Freedom veteransImagery rehearsalOperation Iraqi Freedom veteransSubgroups of veteransIraqi Freedom veteransFrequency questionnaireControlled TrialsPrimary outcomeLikelihood ratio chi-squareStates veteransDistress QuestionnaireStress disorderChi-squareRecurrent nightmaresConfidence intervalsMilitary veteransVeteransCombat veteransNeural computations of threat in the aftermath of combat trauma
Homan P, Levy I, Feltham E, Gordon C, Hu J, Li J, Pietrzak RH, Southwick S, Krystal JH, Harpaz-Rotem I, Schiller D. Neural computations of threat in the aftermath of combat trauma. Nature Neuroscience 2019, 22: 470-476. PMID: 30664770, PMCID: PMC6829910, DOI: 10.1038/s41593-018-0315-x.Peer-Reviewed Original ResearchConceptsPTSD symptomsPost-traumatic stress disorder symptomsHigher PTSD symptom severityThreat-predictive cuesPTSD symptom severityAssociative threatPredictive cuesNeural trackingDisorder symptomsPrediction errorCombat veteransDynamic learning rateNegative outcomesCombat traumaSmaller amygdala volumesNeural computationLatent markersSymptomatic veteransSymptom severityAmygdala volumeAssociabilityCuesLearning rateVeteransSymptoms
2018
Locus of control in US combat veterans: Unique associations with posttraumatic stress disorder 5-factor model symptom clusters
Smith NB, Sippel LM, Presseau C, Rozek D, Mota N, Gordon C, Horvath M, Harpaz-Rotem I. Locus of control in US combat veterans: Unique associations with posttraumatic stress disorder 5-factor model symptom clusters. Psychiatry Research 2018, 268: 152-156. PMID: 30029062, DOI: 10.1016/j.psychres.2018.07.015.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderLocus of controlPTSD symptom clustersOverall PTSD symptomsAvoidance symptomsPTSD symptomsSymptom clustersStress disorderCombat veteransExternal locusCombat exposureCorrelates of PTSDSpecific PTSD symptom clustersTrauma-focused treatmentSelf-report measuresUS combat veteransIntervention effortsUnique associationUS military veteransExtreme scoresPotential correlatesMilitary veteransBivariate correlationsOnly avoidanceSignificant correlates
2017
Mental and Physical Health Conditions in US Combat Veterans: Results From the National Health and Resilience in Veterans Study.
Thomas MM, Harpaz-Rotem I, Tsai J, Southwick SM, Pietrzak RH. Mental and Physical Health Conditions in US Combat Veterans: Results From the National Health and Resilience in Veterans Study. The Primary Care Companion For CNS Disorders 2017, 19 PMID: 28657698, DOI: 10.4088/pcc.17m02118.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsCardiovascular DiseasesCross-Sectional StudiesFemaleHealth StatusHumansMaleMental DisordersMental HealthMiddle AgedMigraine DisordersResilience, PsychologicalSex FactorsSocioeconomic FactorsSubstance-Related DisordersSuicideUnited StatesVeteransWar ExposureYoung AdultConceptsPhysical health conditionsPosttraumatic stress disorderOlder combat veteransCurrent posttraumatic stress disorderGreater oddsHealth conditionsChronic painHeart diseaseUS veteransNational HealthMigraine headacheCombat veteransSuicidal ideationVeterans StudyCurrent generalized anxiety disorderHeart attackVeterans Affairs Healthcare SystemLifetime posttraumatic stress disorderUS veteran populationElevated ratesPopulation-based burdenCurrent psychiatric disorderDrug use disordersMental health factorsGeneralized anxiety disorder
2016
POSTTRAUMATIC STRESS SYMPTOMS AND AVERSION TO AMBIGUOUS LOSSES IN COMBAT VETERANS
Ruderman L, Ehrlich DB, Roy A, Pietrzak RH, Harpaz-Rotem I, Levy I. POSTTRAUMATIC STRESS SYMPTOMS AND AVERSION TO AMBIGUOUS LOSSES IN COMBAT VETERANS. Depression And Anxiety 2016, 33: 606-613. PMID: 27000639, PMCID: PMC5247796, DOI: 10.1002/da.22494.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderCombat veteransAmbiguity attitudesCombat exposureDecision-making taskTrauma-related symptomsAnxious arousal symptomsBehavioral economics techniquesUncertainty attitudesAnxious arousalNeural underpinningsTraditional diagnostic categoriesArousal symptomsStress disorderBehavioral levelBehavioral outcomesParticipants' choicesLoss domainBehavioral economicsPsychiatric symptomsVeteransAttitudesPsychiatric disordersUncertain outcomesUncertain gains