Comparative analysis of aldosterone and renin assays for primary aldosteronism screening
Taki Y, Kono T, Teruyama K, Ichijo T, Sakuma I, Nagano H, Miyagawa H, Kono S, Fujimoto M, Hashimoto N, Yokoyama M, Kawakami E, Miki T, Tanaka T. Comparative analysis of aldosterone and renin assays for primary aldosteronism screening. Scientific Reports 2024, 14: 26040. PMID: 39472614, PMCID: PMC11522277, DOI: 10.1038/s41598-024-75645-1.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAldosteroneChromatography, LiquidFemaleHumansHyperaldosteronismMaleMiddle AgedRadioimmunoassayReninRetrospective StudiesROC CurveTandem Mass SpectrometryConceptsAldosterone-to-renin ratioPlasma aldosterone concentrationWeak mineralocorticoidLC-MS/MSPrimary aldosteronismChemiluminescent enzyme immunoassayAnalysis of aldosteroneLiquid chromatography/mass spectrometry/mass spectrometryPA diagnosisPrimary aldosteronism screeningNon-PA groupPlasma aldosterone concentration valuesReceiver operating characteristic curveRenin samplingRenin valuesAldosterone concentrationRetrospective studyCutoff valuePassing-Bablok regressionPAC samplesRenin assayPAC measurementsRadioimmunoassay methodEnzyme immunoassayRadioimmunoassay