2023
Neural valuation of rewards and punishments in posttraumatic stress disorder: a computational approach
Jia R, Ruderman L, Pietrzak R, Gordon C, Ehrlich D, Horvath M, Mirchandani S, DeFontes C, Southwick S, Krystal J, Harpaz-Rotem I, Levy I. Neural valuation of rewards and punishments in posttraumatic stress disorder: a computational approach. Translational Psychiatry 2023, 13: 101. PMID: 36977676, PMCID: PMC10050320, DOI: 10.1038/s41398-023-02388-4.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderValuation systemStress disorderCombat veteransMaintenance of PTSDSubjective valueBrain valuation systemNeural valuation systemVentromedial prefrontal cortexFunctional MRI studyFunction of symptomsMale combat veteransNeural valuationSeries of choicesFear learningPunishment processingPosttrauma symptomsPTSD symptomsNeural encodingNeural mechanismsUncertain optionsPrefrontal cortexSubjective valuationVentral striatumMonetary gains
2017
Distributed neural representation of saliency controlled value and category during anticipation of rewards and punishments
Zhang Z, Fanning J, Ehrlich DB, Chen W, Lee D, Levy I. Distributed neural representation of saliency controlled value and category during anticipation of rewards and punishments. Nature Communications 2017, 8: 1907. PMID: 29203854, PMCID: PMC5714958, DOI: 10.1038/s41467-017-02080-4.Peer-Reviewed Original ResearchConceptsNeural representationAnticipation of rewardDecision-related informationCognitive neuroscienceOutcome anticipationValue signalsPotential confoundsCategory informationHuman brainNeural signalsSaliencyRewardValuation taskAnticipationMultiple aspectsStrong supportActivity patternsPunishmentVmPFCRepresentationNeuroscienceConfoundsExtensive literatureEncodingTask