2024
Cross-tissue organization of myeloid cells in scleroderma and related fibrotic diseases
Odell I. Cross-tissue organization of myeloid cells in scleroderma and related fibrotic diseases. Current Opinion In Rheumatology 2024, 36: 379-386. PMID: 39171604, PMCID: PMC11451931, DOI: 10.1097/bor.0000000000001047.Peer-Reviewed Original ResearchScRNA-seqIdiopathic pulmonary fibrosisMyeloid cell typesScRNA-seq studiesScRNA-seq analysisSingle-cell RNA sequencingCell typesDendritic cellsFc receptor genesScleroderma skinExpression of EREGLung fibrosis severityFibrotic diseasesMyeloid cell populationsRNA sequencingMultiple tissuesSignaling mechanismsReceptor geneMyeloid cellsSSc skinPulmonary fibrosisFibrosis severityLung fibrosisCardiac fibrosisSPP1
2023
IL-6 trans-signaling in a humanized mouse model of scleroderma
Odell I, Agrawal K, Sefik E, Odell A, Caves E, Kirkiles-Smith N, Horsley V, Hinchcliff M, Pober J, Kluger Y, Flavell R. IL-6 trans-signaling in a humanized mouse model of scleroderma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2306965120. PMID: 37669366, PMCID: PMC10500188, DOI: 10.1073/pnas.2306965120.Peer-Reviewed Original ResearchConceptsBone marrow-derived immune cellsIL-6Human hematopoietic stem cellsImmune cellsT cellsScleroderma skinSoluble IL-6 receptorCD8 T cellsHumanized mouse modelPathogenesis of sclerodermaMesenchymal cellsFibroblast-derived IL-6IL-6 receptorIL-6 signalingT cell activationHuman IL-6Human T cellsExpression of collagenFibrosis improvementPansclerotic morpheaHuman endothelial cellsHumanized miceReduced markersSkin graftsHuman CD4