Somatic p.T771R KDR (VEGFR2) Mutation Arising in a Sporadic Angioma During Ramucirumab Therapy
Lim YH, Odell ID, Ko CJ, Choate KA. Somatic p.T771R KDR (VEGFR2) Mutation Arising in a Sporadic Angioma During Ramucirumab Therapy. JAMA Dermatology 2015, 151: 1240-1243. PMID: 26422291, DOI: 10.1001/jamadermatol.2015.1925.Peer-Reviewed Original ResearchConceptsVascular endothelial growth factor 2Vascular lesionsRamucirumab therapyNon-small cell lung carcinomaExome sequencingNew vascular lesionsMetastatic rectal cancerCell lung carcinomaRich blood supplySomatic mutationsInhibition of angiogenesisVia exome sequencingPotential adverse effectsRight shinAntiangiogenic therapeuticsGrowth factor 2Rectal cancerCombination therapyVascular tumorsGastric adenocarcinomaHistological featuresLung carcinomaBlood supplyRight legIrinotecan hydrochloride