Featured Publications
Epiregulin is a dendritic cell–derived EGFR ligand that maintains skin and lung fibrosis
Odell I, Steach H, Gauld S, Reinke-Breen L, Karman J, Carr T, Wetter J, Phillips L, Hinchcliff M, Flavell R. Epiregulin is a dendritic cell–derived EGFR ligand that maintains skin and lung fibrosis. Science Immunology 2022, 7: eabq6691. PMID: 36490328, PMCID: PMC9840167, DOI: 10.1126/sciimmunol.abq6691.Peer-Reviewed Original ResearchConceptsLung fibrosisDendritic cellsImmune cellsDiffuse cutaneous systemic sclerosisPersistence of fibrosisCutaneous systemic sclerosisExtent of fibrosisType I interferonSystemic sclerosisAutoimmune diseasesAntifibrotic targetsTherapeutic administrationMouse modelI interferonLung samplesLung explantsFibrosisFibrotic tissueImmune signalsEpiregulin expressionPatient's skinExtracellular matrix productionGenetic deficiencyEpiregulinEGFR ligands
2024
Cross-tissue organization of myeloid cells in scleroderma and related fibrotic diseases
Odell I. Cross-tissue organization of myeloid cells in scleroderma and related fibrotic diseases. Current Opinion In Rheumatology 2024, 36: 379-386. PMID: 39171604, PMCID: PMC11451931, DOI: 10.1097/bor.0000000000001047.Peer-Reviewed Original ResearchScRNA-seqIdiopathic pulmonary fibrosisMyeloid cell typesScRNA-seq studiesScRNA-seq analysisSingle-cell RNA sequencingCell typesDendritic cellsFc receptor genesScleroderma skinExpression of EREGLung fibrosis severityFibrotic diseasesMyeloid cell populationsRNA sequencingMultiple tissuesSignaling mechanismsReceptor geneMyeloid cellsSSc skinPulmonary fibrosisFibrosis severityLung fibrosisCardiac fibrosisSPP1