Morphea after Borrelia-induced facial nerve palsy
Xie CB, Cowper S, Odell ID. Morphea after Borrelia-induced facial nerve palsy. Journal Of Scleroderma And Related Disorders 2020, 6: 111-113. PMID: 35382252, PMCID: PMC8922639, DOI: 10.1177/2397198320956892.Peer-Reviewed Case Reports and Technical NotesFacial nerve palsyNerve palsyDevelopment of morpheaLocal immune toleranceFacial nerve paralysisAutoimmune phenomenaMost patientsNerve paralysisExact pathogenesisImmune toleranceAutoimmune diseasesHost antigensLocalized sclerodermaCommon causeFamily historyMorpheaEndemic areasGenetic predispositionPrevious episodesPalsyYoung menPrevious casesEnvironmental insultsInfectionBorreliaEpiregulin is a dendritic cell–derived EGFR ligand that maintains skin and lung fibrosis
Odell I, Steach H, Gauld S, Reinke-Breen L, Karman J, Carr T, Wetter J, Phillips L, Hinchcliff M, Flavell R. Epiregulin is a dendritic cell–derived EGFR ligand that maintains skin and lung fibrosis. Science Immunology 2022, 7: eabq6691. PMID: 36490328, PMCID: PMC9840167, DOI: 10.1126/sciimmunol.abq6691.Peer-Reviewed Original ResearchConceptsLung fibrosisDendritic cellsImmune cellsDiffuse cutaneous systemic sclerosisPersistence of fibrosisCutaneous systemic sclerosisExtent of fibrosisType I interferonSystemic sclerosisAutoimmune diseasesAntifibrotic targetsTherapeutic administrationMouse modelI interferonLung samplesLung explantsFibrosisFibrotic tissueImmune signalsEpiregulin expressionPatient's skinExtracellular matrix productionGenetic deficiencyEpiregulinEGFR ligands