1989
Initiation of Fetal Rat Lung Phospholipid and Surfactant-Associated Protein A mRNA Synthesis
Gross I, Wilson C, Floros J, Dynia D. Initiation of Fetal Rat Lung Phospholipid and Surfactant-Associated Protein A mRNA Synthesis. Pediatric Research 1989, 25: 239-244. PMID: 2704589, DOI: 10.1203/00006450-198903000-00004.Peer-Reviewed Original ResearchConceptsRU 486Lung tissueGlucocorticoid agonist activityRat lung phospholipidsAntagonist RU 486Steroid antagonist RU 486Surfactant-associated protein AFetal rat lungGlucocorticoid antagonistSurfactant associated proteinsLung phospholipidsSurfactant-associated proteinsFetal lungRat lungSurfactant productionComponents of surfactantSignificant increaseGlucocorticoidsLungControl explantsSpecific cytoplasmicPhosphatidylcholine synthesisSame extentPhospholipid productionTissue
1985
Influence of Theophylline on Fetal Rat Lung Phosphatidylcholine Synthesis in vivo
Moya F, Gross I. Influence of Theophylline on Fetal Rat Lung Phosphatidylcholine Synthesis in vivo. Neonatology 1985, 8: 9-16. PMID: 3987490, DOI: 10.1159/000457017.Peer-Reviewed Original ResearchConceptsSerum levelsFetal lung surfactant productionInfluence of theophyllineLung tissue concentrationsElevated serum levelsDoses of theophyllineLung surfactant productionPhosphatidylcholine synthesisMaternal ratioPregnant ratsIntraperitoneal administrationTissue concentrationsRate of incorporationSurfactant productionTheophyllineVivoFetusesRatsAdministrationDoses
1984
COMBINED HORMONAL THERAPY MAY DECREASE THE TIME NEEDED FOR INDUCTION OF LUNG SURFACTANT PRODUCTION
Moya F, Gross I. COMBINED HORMONAL THERAPY MAY DECREASE THE TIME NEEDED FOR INDUCTION OF LUNG SURFACTANT PRODUCTION. Pediatric Research 1984, 18: 142-142. DOI: 10.1203/00006450-198404001-00296.Peer-Reviewed Original ResearchLung surfactant productionHormonal therapyFetal ratsDay 20Surfactant productionPregnant Sprague-Dawley ratsFetal lung maturationSprague-Dawley ratsCombination of hormonesMaternal administrationCombined therapyLung maturationMaternal injectionLung mincesThyroid hormonesCholine incorporationSurfactant synthesisTherapyRatsStatistical significanceRecent evidenceCorticosteroidsBetamethasoneFetusesAdditive effect
1983
Lung surfactant in the hyperinsulinemic fetal monkey
Rooney S, Chu A, Gross I, Marino P, Schwartz R, Seghal P, Singer D, Susa J, Warshaw J, Wilson C. Lung surfactant in the hyperinsulinemic fetal monkey. Lung 1983, 161: 313-317. PMID: 6355669, DOI: 10.1007/bf02713877.Peer-Reviewed Original ResearchConceptsAbsence of hyperglycemiaBlood insulin levelsFetal rhesus monkeysEffect of hyperinsulinemiaInfusion of insulinSurfactant productionLung surfactant productionDiabetic mothersAlzet minipumpsInsulin levelsD gestationFetal monkeysFetal primateLung lavageLung tissueDays gestationLung slicesBody weightControl groupRhesus monkeysHyperinsulinemiaGestationCholine incorporationInhibitory effectHuman infants
1979
Thyrotropin-Releasing Hormone Increases the Amount of Surfactant in Lung Lavage from Fetal Rabbits
Rooney S, Marino P, Gobran L, Gross I, Warshaw J. Thyrotropin-Releasing Hormone Increases the Amount of Surfactant in Lung Lavage from Fetal Rabbits. Pediatric Research 1979, 13: 623-625. PMID: 112569, DOI: 10.1203/00006450-197905000-00009.Peer-Reviewed Original ResearchConceptsThyrotropin-releasing hormoneLung lavageLung maturationFetal lung slicesRespiratory distress syndromeFetal lung maturationPulmonary surfactant productionSurfactant productionPhosphatidylcholine/sphingomyelin ratioDistress syndromeTRH administrationPregnant rabbitsIncorporation of cholineFetal rabbitsGestation resultsLung slicesLavagePhysiologic roleFetusesSphingomyelin ratioTotal phospholipidsControl littersSurfactant releasePhospholipid contentMore phosphatidylcholineEffects of betamethasone on phospholipid content, composition and biosynthesis in the fetal rabbit lung
Rooney S, Gobran L, Marino P, Maniscalco W, Gross I. Effects of betamethasone on phospholipid content, composition and biosynthesis in the fetal rabbit lung. Biochimica Et Biophysica Acta 1979, 572: 64-76. PMID: 216408, DOI: 10.1016/0005-2760(79)90200-5.Peer-Reviewed Original ResearchConceptsLung lavageFetal lung lavageFetal lung slicesAdministration of betamethasoneEffect of betamethasoneFetal lung maturationFetal rabbit lungPhosphatidylcholine/sphingomyelin ratioLung glycogenBetamethasone administrationLung maturationPregnant rabbitsDays gestationFetal lungLung slicesRabbit lungsStress-induced accelerationDirect administrationSphingomyelin ratioSurfactant phospholipidsBetamethasoneAdministrationRate of incorporationSurfactant productionLavage
1975
Stimulation of glycerolphosphate phosphatidyltransferase activity in fetal rabbit lung by cortisol administration
Rooney S, Gross I, Gassenheimer L, Motoyama E. Stimulation of glycerolphosphate phosphatidyltransferase activity in fetal rabbit lung by cortisol administration. Biochimica Et Biophysica Acta 1975, 398: 433-441. PMID: 1242106, DOI: 10.1016/0005-2760(75)90194-0.Peer-Reviewed Original ResearchConceptsAdministration of cortisolFetal rabbit lungLysolecithin acyltransferase activityLung maturationLiver enzymesDays gestationFetal rabbitsThyroxine treatmentGestation resultsCortisol administrationRabbit lungsCortisol treatmentDirect administrationAdministrationPulmonary surfactantSurfactant productionSignificant increaseGestationCholine phosphotransferaseAcyltransferase activityTreatmentCorticosteroidsPrevious studiesLungFetusesThe inhibition of enzymes related to pulmonary fatty acid and phospholipid synthesis by dietary deprivation in the rat
Gross I, Rooney S, Warshaw J. The inhibition of enzymes related to pulmonary fatty acid and phospholipid synthesis by dietary deprivation in the rat. Biochemical And Biophysical Research Communications 1975, 64: 59-63. PMID: 238512, DOI: 10.1016/0006-291x(75)90219-3.Peer-Reviewed Original ResearchConceptsPulmonary surfactant productionMicrosomal fatty acid elongationDietary deprivationRat lungFatty acid synthetaseDeprivation resultsAcute starvationInhibition of enzymesAcetyl-CoA carboxylaseSurfactant productionKnown inhibitionSignificant reductionFatty acid elongationFatty acidsInhibitionPhospholipid synthesisLung