1986
Glucocorticoid stimulation of choline-phosphate cytidylyltransferase activity in fetal rat lung: Receptor-response relationships
Rooney S, Dynia D, Smart D, Chu A, Ingleson L, Wilson C, Gross I. Glucocorticoid stimulation of choline-phosphate cytidylyltransferase activity in fetal rat lung: Receptor-response relationships. Biochimica Et Biophysica Acta 1986, 888: 208-216. PMID: 3017448, DOI: 10.1016/0167-4889(86)90023-6.Peer-Reviewed Original ResearchConceptsEffect of dexamethasoneDexamethasone bindingCholine-phosphate cytidylyltransferase activitySpecific dexamethasone bindingFetal lung maturationFetal rat lung explantsCholine-phosphate cytidylyltransferaseSpecific nuclear bindingCytidylyltransferase activityRat lung explantsReceptor-mediated processSupernatant fractionFetal rat lungDose-response curveDexamethasone-treated culturesLung maturationGlucocorticoid bindingGlucocorticoid actionDe novo phosphatidylcholine synthesisLung explantsRat lungDexamethasoneGlucocorticoid stimulationStimulatory effectCholine incorporation
1984
DO EGF AND GLUCOCORTICOIDS ACT AT THE SAME METABOLIC SITES IN FETAL RAT LUNG?
Gross I, Dynia D. DO EGF AND GLUCOCORTICOIDS ACT AT THE SAME METABOLIC SITES IN FETAL RAT LUNG? Pediatric Research 1984, 18: 392-392. DOI: 10.1203/00006450-198404001-01797.Peer-Reviewed Original ResearchFetal rat lungCholine incorporationEffect of EGFRat lungFetal lung maturationEffect of DexDose-dependent fashionMetabolic sitesGestational ageLung maturationOrgan culture systemFetal lungGlucocorticoids actSerum-free organ culture systemMaximal effectDistribution of radioactivityThymidine incorporationMouse skinLungDependent fashionBiochemical developmentPhosphatidylglycerol fractionT3T4 actionEGFCOMBINED HORMONAL THERAPY MAY DECREASE THE TIME NEEDED FOR INDUCTION OF LUNG SURFACTANT PRODUCTION
Moya F, Gross I. COMBINED HORMONAL THERAPY MAY DECREASE THE TIME NEEDED FOR INDUCTION OF LUNG SURFACTANT PRODUCTION. Pediatric Research 1984, 18: 142-142. DOI: 10.1203/00006450-198404001-00296.Peer-Reviewed Original ResearchLung surfactant productionHormonal therapyFetal ratsDay 20Surfactant productionPregnant Sprague-Dawley ratsFetal lung maturationSprague-Dawley ratsCombination of hormonesMaternal administrationCombined therapyLung maturationMaternal injectionLung mincesThyroid hormonesCholine incorporationSurfactant synthesisTherapyRatsStatistical significanceRecent evidenceCorticosteroidsBetamethasoneFetusesAdditive effect
1983
Fetal rat lung maturation: initiation and modulation
Gross I, Wilson C. Fetal rat lung maturation: initiation and modulation. Journal Of Applied Physiology 1983, 55: 1725-1732. PMID: 6662763, DOI: 10.1152/jappl.1983.55.6.1725.Peer-Reviewed Original ResearchConceptsFetal lung maturationGestational ageLung maturationCholine incorporationEquivalent gestational ageFetal rat lungGlucocorticoid bindingDays gestationLung tissueFetal lungRat lungBiochemical markersLung developmentMorphological maturationDSPC contentMesenchymal tissueMaturational processesMarked increaseHormoneSimilar increaseLungLate modulationPhosphatidylcholine synthesisAgeMaturation
1982
Fetal lung in organ culture. IV. Supra-additive hormone interactions
Gross I, Wilson C. Fetal lung in organ culture. IV. Supra-additive hormone interactions. Journal Of Applied Physiology 1982, 52: 1420-1425. PMID: 6286561, DOI: 10.1152/jappl.1982.52.6.1420.Peer-Reviewed Original ResearchConceptsFetal lung maturationLung maturationSupra-additive interactionOrgan cultureCombination of dexamethasoneRate of incorporationFetal rat lungVivo animal studiesHormone administrationFetal lungAnimal studiesRat lungSupra-additive stimulationThyroid hormonesNM dexamethasoneDexamethasone concentrationsMaximal stimulationLungDexamethasoneNM triiodothyroninePulmonary surfactantSignificant increaseStimulationPrecursor incorporationCyclic monophosphate
1981
Organotypic Culture of Fetal Rat Lung: Evaluation and Comparison with Organ Culture1–3
Gross I, Freedman R, Wilson C, Lindsey S. Organotypic Culture of Fetal Rat Lung: Evaluation and Comparison with Organ Culture1–3. American Journal Of Respiratory And Critical Care Medicine 1981, 123: 313-9. PMID: 7224342, DOI: 10.1164/arrd.1981.123.3.313.Peer-Reviewed Original Research
1979
The Hormonal Regulation of Fetal Lung Maturation
Gross I. The Hormonal Regulation of Fetal Lung Maturation. Clinics In Perinatology 1979, 6: 377-395. PMID: 230006, DOI: 10.1016/s0095-5108(18)31155-2.ChaptersThyrotropin-Releasing Hormone Increases the Amount of Surfactant in Lung Lavage from Fetal Rabbits
Rooney S, Marino P, Gobran L, Gross I, Warshaw J. Thyrotropin-Releasing Hormone Increases the Amount of Surfactant in Lung Lavage from Fetal Rabbits. Pediatric Research 1979, 13: 623-625. PMID: 112569, DOI: 10.1203/00006450-197905000-00009.Peer-Reviewed Original ResearchConceptsThyrotropin-releasing hormoneLung lavageLung maturationFetal lung slicesRespiratory distress syndromeFetal lung maturationPulmonary surfactant productionSurfactant productionPhosphatidylcholine/sphingomyelin ratioDistress syndromeTRH administrationPregnant rabbitsIncorporation of cholineFetal rabbitsGestation resultsLung slicesLavagePhysiologic roleFetusesSphingomyelin ratioTotal phospholipidsControl littersSurfactant releasePhospholipid contentMore phosphatidylcholineEffects of betamethasone on phospholipid content, composition and biosynthesis in the fetal rabbit lung
Rooney S, Gobran L, Marino P, Maniscalco W, Gross I. Effects of betamethasone on phospholipid content, composition and biosynthesis in the fetal rabbit lung. Biochimica Et Biophysica Acta 1979, 572: 64-76. PMID: 216408, DOI: 10.1016/0005-2760(79)90200-5.Peer-Reviewed Original ResearchConceptsLung lavageFetal lung lavageFetal lung slicesAdministration of betamethasoneEffect of betamethasoneFetal lung maturationFetal rabbit lungPhosphatidylcholine/sphingomyelin ratioLung glycogenBetamethasone administrationLung maturationPregnant rabbitsDays gestationFetal lungLung slicesRabbit lungsStress-induced accelerationDirect administrationSphingomyelin ratioSurfactant phospholipidsBetamethasoneAdministrationRate of incorporationSurfactant productionLavage
1977
AN ORGAN CULTURE MODEL FOR THE STUDY OF FETAL LUNG MATURATION
Gross I, Czaika M, Walker Smith G, Warahaw J. AN ORGAN CULTURE MODEL FOR THE STUDY OF FETAL LUNG MATURATION. Pediatric Research 1977, 11: 406-406. DOI: 10.1203/00006450-197704000-00220.Peer-Reviewed Original ResearchOrgan culture modelLate-gestation fetal rat lungAlveolar lining cellsFetal lung maturationFresh lung tissueShort-term organ cultureFetal rat lungCulture modelDay fetal ratsLung maturationCentral necrosisLung tissueFetal lungFetal ratsLining cellsHormonal influencesBiochemical findingsRat lungLung developmentStromal tissueTissue chopperDay fetusesMorphologic maturationMorphological maturationGlycogen content