1997
Inhaled Nitric Oxide and Persistent Pulmonary Hypertension of the Newborn
Roberts J, Fineman J, Morin F, Shaul P, Rimar S, Schreiber M, Polin R, Zwass M, Zayek M, Gross I, Heymann M, Zapol W, Thusu K, Zellers T, Wylam M, Zaslavsky A. Inhaled Nitric Oxide and Persistent Pulmonary Hypertension of the Newborn. New England Journal Of Medicine 1997, 336: 605-610. PMID: 9032045, DOI: 10.1056/nejm199702273360902.Peer-Reviewed Original ResearchConceptsPersistent pulmonary hypertensionPulmonary vascular resistanceExtracorporeal membrane oxygenationPulmonary hypertensionSystemic oxygenationNitric oxideSevere hypoxemiaVascular resistanceMembrane oxygenationSystemic arterial hypoxemiaSystemic blood pressureLong-term therapyFull-term infantsNumber of deathsSystemic hypotensionArterial hypoxemiaBlood pressureMulticenter studyConventional therapyAlternative therapiesInvasive treatmentNitric oxide groupHypertensionInitial improvementMethemoglobin levels
1989
Survival of infants with persistent pulmonary hypertension without extracorporeal membrane oxygenation.
Dworetz A, Moya F, Sabo B, Gladstone I, Gross I. Survival of infants with persistent pulmonary hypertension without extracorporeal membrane oxygenation. Pediatrics 1989, 84: 1-6. PMID: 2740158, DOI: 10.1542/peds.84.1.1.Peer-Reviewed Original ResearchConceptsPersistent pulmonary hypertensionPulmonary hypertensionExtracorporeal membrane oxygenation therapyCorresponding survival figuresMembrane oxygenation therapyExtracorporeal membrane oxygenationRecords of infantsSurvival of infantsConservative therapyMembrane oxygenationOxygenation therapySurvival figuresRetrospective evaluationMortality rateHypertensionECMOTherapyPatientsInfantsConservative approachSurvivalEarly periodHyperventilationCriteriaMainstay