2001
Is there a role for antenatal TRH therapy for the prevention of neonatal lung disease?
Gross I, Moya F. Is there a role for antenatal TRH therapy for the prevention of neonatal lung disease? Seminars In Perinatology 2001, 25: 406-416. PMID: 11778911, DOI: 10.1053/sper.2001.29032.Peer-Reviewed Original ResearchConceptsAntenatal thyrotropin-releasing hormoneThyrotropin-releasing hormoneRespiratory distress syndromeSurfactant therapyDistress syndromeOxygen dependencyAntenatal glucocorticoid treatmentLight-headed feelingPatent ductus arteriosusRetinopathy of prematurityNeonatal lung diseaseRandomized clinical trialsPituitary-thyroid axisAddition of TRHAntenatal glucocorticoidsGlucocorticoid therapyMaternal therapyNeonatal complicationsTransient complicationsTRH therapyHormone therapyBlood pressureDuctus arteriosusGlucocorticoid treatmentLung disease
1997
Inhaled Nitric Oxide and Persistent Pulmonary Hypertension of the Newborn
Roberts J, Fineman J, Morin F, Shaul P, Rimar S, Schreiber M, Polin R, Zwass M, Zayek M, Gross I, Heymann M, Zapol W, Thusu K, Zellers T, Wylam M, Zaslavsky A. Inhaled Nitric Oxide and Persistent Pulmonary Hypertension of the Newborn. New England Journal Of Medicine 1997, 336: 605-610. PMID: 9032045, DOI: 10.1056/nejm199702273360902.Peer-Reviewed Original ResearchConceptsPersistent pulmonary hypertensionPulmonary vascular resistanceExtracorporeal membrane oxygenationPulmonary hypertensionSystemic oxygenationNitric oxideSevere hypoxemiaVascular resistanceMembrane oxygenationSystemic arterial hypoxemiaSystemic blood pressureLong-term therapyFull-term infantsNumber of deathsSystemic hypotensionArterial hypoxemiaBlood pressureMulticenter studyConventional therapyAlternative therapiesInvasive treatmentNitric oxide groupHypertensionInitial improvementMethemoglobin levels