2017
Transport of the alpha subunit of the voltage gated L‐type calcium channel through the sarcoplasmic reticulum occurs prior to localization to triads and requires the beta subunit but not Stac3 in skeletal muscles
Linsley JW, Hsu I, Wang W, Kuwada JY. Transport of the alpha subunit of the voltage gated L‐type calcium channel through the sarcoplasmic reticulum occurs prior to localization to triads and requires the beta subunit but not Stac3 in skeletal muscles. Traffic 2017, 18: 622-632. PMID: 28697281, PMCID: PMC5569907, DOI: 10.1111/tra.12502.Peer-Reviewed Original ResearchConceptsEC couplingL-type calcium channelsSkeletal muscleL-type voltageExcitation-contraction couplingCongenital myopathyCalcium channelsLongitudinal SRSarcoplasmic reticulumDHPRMembrane depolarizationMuscle fibersTubule membranesMuscleSR membranesAlpha subunitSarcoplasmic reticulum membranesDynamic imagingBeta subunitMembrane voltageTriadPrecise localizationTherapyMyopathy
2016
Congenital myopathy results from misregulation of a muscle Ca2+ channel by mutant Stac3
Linsley JW, Hsu IU, Groom L, Yarotskyy V, Lavorato M, Horstick EJ, Linsley D, Wang W, Franzini-Armstrong C, Dirksen RT, Kuwada JY. Congenital myopathy results from misregulation of a muscle Ca2+ channel by mutant Stac3. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 114: e228-e236. PMID: 28003463, PMCID: PMC5240691, DOI: 10.1073/pnas.1619238114.Peer-Reviewed Original ResearchConceptsEC couplingDihydropyridine receptorNative American myopathySarcoplasmic reticulumExcitation-contraction couplingSkeletal muscle contractionVoltage-sensing dihydropyridine receptorCaffeine-induced CaRyanodine receptor 1Receptor 1Muscle contractionInternal storesMuscle Ca2Muscle fibersSTAC3Luminal CaMyopathyTransverse tubule membranesTubule membranesCaffeine sensitivityHuman myopathiesCoupling apparatusHuman diseasesDynamic imagingCritical role