2014
Genotype and risk of major bleeding during warfarin treatment
Kawai V, Cunningham A, Vear S, Van Driest S, Oginni A, Xu H, Jiang M, Li C, Denny J, Shaffer C, Bowton E, Gage B, Ray W, Roden D, Stein C. Genotype and risk of major bleeding during warfarin treatment. Pharmacogenomics 2014, 15: 1973-1983. PMID: 25521356, PMCID: PMC4304738, DOI: 10.2217/pgs.14.153.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiological Specimen BanksCytochrome P-450 CYP2C9Cytochrome P-450 Enzyme SystemCytochrome P450 Family 4Dose-Response Relationship, DrugEthnicityFemaleGene FrequencyGenetic Association StudiesGenetic VariationGenotypeHemorrhageHumansMaleMiddle AgedRisk FactorsVitamin K Epoxide ReductasesWarfarin
2012
Predicting warfarin dosage in EuropeanAmericans and AfricanAmericans using DNA samples linked to an electronic health record
Ramirez A, Shi Y, Schildcrout J, Delaney J, Xu H, Oetjens M, Zuvich R, Basford M, Bowton E, Jiang M, Speltz P, Zink R, Cowan J, Pulley J, Ritchie M, Masys D, Roden D, Crawford D, Denny J. Predicting warfarin dosage in EuropeanAmericans and AfricanAmericans using DNA samples linked to an electronic health record. Pharmacogenomics 2012, 13: 407-418. PMID: 22329724, PMCID: PMC3361510, DOI: 10.2217/pgs.11.164.Peer-Reviewed Original ResearchAdultAgedAged, 80 and overAnticoagulantsAryl Hydrocarbon HydroxylasesBlack or African AmericanCalcium-Binding ProteinsCytochrome P-450 CYP2C9Cytochrome P-450 Enzyme SystemCytochrome P450 Family 4Dose-Response Relationship, DrugDrug Administration ScheduleElectronic Health RecordsFemaleHumansMaleMiddle AgedMixed Function OxygenasesPolymorphism, Single NucleotideSubstance-Related DisordersVitamin K Epoxide ReductasesWarfarinWhite People
2011
Modeling drug exposure data in electronic medical records: an application to warfarin.
Liu M, Jiang M, Kawai V, Stein C, Roden D, Denny J, Xu H. Modeling drug exposure data in electronic medical records: an application to warfarin. AMIA Annual Symposium Proceedings 2011, 2011: 815-23. PMID: 22195139, PMCID: PMC3243123.Peer-Reviewed Original ResearchConceptsNatural language processingMachine learning technologiesElectronic medical recordsDrug exposure informationLearning technologyLanguage processingTemporal informationInformatics frameworkClinical narrativesDrug mentionsMedical recordsDrug exposure dataFrameworkReceiver operator characteristic curveDrug exposure historyInformationDrug-related researchWarfarin exposureDrug regimensHospital admissionDrug exposureAccurate modelingDrug informationExposure informationExposure dataFacilitating pharmacogenetic studies using electronic health records and natural-language processing: a case study of warfarin
Xu H, Jiang M, Oetjens M, Bowton E, Ramirez A, Jeff J, Basford M, Pulley J, Cowan J, Wang X, Ritchie M, Masys D, Roden D, Crawford D, Denny J. Facilitating pharmacogenetic studies using electronic health records and natural-language processing: a case study of warfarin. Journal Of The American Medical Informatics Association 2011, 18: 387-391. PMID: 21672908, PMCID: PMC3128409, DOI: 10.1136/amiajnl-2011-000208.Peer-Reviewed Original ResearchAlgorithmsAnticoagulantsAryl Hydrocarbon HydroxylasesCytochrome P-450 CYP2C9Data MiningDatabases, Nucleic AcidDrug Dosage CalculationsElectronic Health RecordsGenome-Wide Association StudyHumansLinear ModelsMixed Function OxygenasesNatural Language ProcessingPharmacogeneticsPrecision MedicineUnited StatesVitamin K Epoxide ReductasesWarfarin