2024
Repurposing non-pharmacological interventions for Alzheimer's disease through link prediction on biomedical literature
Xiao Y, Hou Y, Zhou H, Diallo G, Fiszman M, Wolfson J, Zhou L, Kilicoglu H, Chen Y, Su C, Xu H, Mantyh W, Zhang R. Repurposing non-pharmacological interventions for Alzheimer's disease through link prediction on biomedical literature. Scientific Reports 2024, 14: 8693. PMID: 38622164, PMCID: PMC11018822, DOI: 10.1038/s41598-024-58604-8.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseManual therapy techniquesR-GCNKnowledge graphAD preventionNon-pharmacological interventionsBiomedical literatureGraph convolutional network modelKG embedding modelsTest setLink prediction modelIntegrated healthConvolutional network modelImprove cognitive functionHighest scoring candidatesDomain expertsEmbedding modelNon-pharmaceutical interventionsReal-world data analysisGround truthPrevent ADCognitive functionTherapy techniquesNetwork modelDiscovery patterns
2023
Repurposing Drugs for Alzheimer's Diseases through Link Prediction on Biomedical Literature
Xiao Y, Hou Y, Zhou H, Diallo G, Fiszman M, Wolfson J, Kilicoglu H, Chen Y, Xu H, Mantyh W, Zhang R. Repurposing Drugs for Alzheimer's Diseases through Link Prediction on Biomedical Literature. 2023, 00: 750-752. DOI: 10.1109/ichi57859.2023.00137.Peer-Reviewed Original ResearchAlzheimer's diseaseKnowledge graphKnowledge graph embedding modelsGraph convolutional network modelComputational drug repurposingGraph embedding modelsTest setConvolutional network modelBiomedical knowledge graphComprehensive knowledge graphDietary supplementsR-GCNEmbedding modelDrug repurposingLink predictionPrediction taskSemantic triplesNetwork modelAlzheimerBiomedical literatureNovel drugsRepurposed drugsGraph