2013
Opioid Use After Cardiac Surgery in Children With Down Syndrome*
Van Driest S, Shah A, Marshall M, Xu H, Smith A, McGregor T, Kannankeril J. Opioid Use After Cardiac Surgery in Children With Down Syndrome*. Pediatric Critical Care Medicine 2013, 14: 862-868. PMID: 23962833, PMCID: PMC3830692, DOI: 10.1097/pcc.0b013e31829f5d9d.Peer-Reviewed Original ResearchConceptsCardiac bypass timeCumulative opioid dosesOpioid dosesCardiac surgeryDown syndromeOpioid doseBypass timePeak serum creatinine valuesRetrospective observational comparative studyNonsteroidal anti-inflammatory drugsElectronic medical record dataAdditional operative proceduresLonger hospital staySerum creatinine valuesObservational comparative studyPediatric teaching hospitalNeuromuscular blocking agentsMedical record dataAnti-inflammatory drugsOpioid resistanceHospital stayOpioid exposureOpioid medicationsPain scoresLonger hospitalization
2012
The use of a DNA biobank linked to electronic medical records to characterize pharmacogenomic predictors of tacrolimus dose requirement in kidney transplant recipients
Birdwell K, Grady B, Choi L, Xu H, Bian A, Denny J, Jiang M, Vranic G, Basford M, Cowan J, Richardson D, Robinson M, Ikizler T, Ritchie M, Stein C, Haas D. The use of a DNA biobank linked to electronic medical records to characterize pharmacogenomic predictors of tacrolimus dose requirement in kidney transplant recipients. Pharmacogenetics And Genomics 2012, 22: 32-42. PMID: 22108237, PMCID: PMC3237759, DOI: 10.1097/fpc.0b013e32834e1641.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 1Body WeightCytochrome P-450 CYP3ADatabases, Nucleic AcidDose-Response Relationship, DrugDrug MonitoringElectronic Health RecordsFemaleGenetic Association StudiesGenotypeHemoglobinsHumansImmunosuppressive AgentsKidney TransplantationLinkage DisequilibriumMaleMiddle AgedPolymorphism, Single NucleotidePregnane X ReceptorReceptors, SteroidTacrolimusConceptsTacrolimus dose requirementsKidney transplant recipientsDose requirementsElectronic medical recordsBlood concentrationsTransplant recipientsMedical recordsCYP3A5 rs776746Electronic medical record dataInterindividual pharmacokinetic variabilityTacrolimus blood concentrationsNarrow therapeutic indexDNA biobanksMedical record dataTherapeutic drug monitoringDrug-metabolizing enzymesKidney transplantationClinical factorsPrimary outcomeImmunosuppressive drugsPharmacokinetic variabilityTacrolimus clearanceClinical covariatesPharmacogenomic predictorsTherapeutic index
2010
MedEx: a medication information extraction system for clinical narratives
Xu H, Stenner S, Doan S, Johnson K, Waitman L, Denny J. MedEx: a medication information extraction system for clinical narratives. Journal Of The American Medical Informatics Association 2010, 17: 19-24. PMID: 20064797, PMCID: PMC2995636, DOI: 10.1197/jamia.m3378.Peer-Reviewed Original ResearchConceptsClinic visit notesVisit notesMedication informationClinical notesDischarge summariesElectronic medical record dataMedical record dataElectronic medical recordsMedication dataMedical recordsClinical dataClinical researchRecord dataHealthcare safetyDrug namesMedexF-measureClinical narrativesNatural language processing systemsInformation extraction system