A Powerful Approach to Estimating Annotation-Stratified Genetic Covariance via GWAS Summary Statistics
Lu Q, Li B, Ou D, Erlendsdottir M, Powles RL, Jiang T, Hu Y, Chang D, Jin C, Dai W, He Q, Liu Z, Mukherjee S, Crane PK, Zhao H. A Powerful Approach to Estimating Annotation-Stratified Genetic Covariance via GWAS Summary Statistics. American Journal Of Human Genetics 2017, 101: 939-964. PMID: 29220677, PMCID: PMC5812911, DOI: 10.1016/j.ajhg.2017.11.001.Peer-Reviewed Original ResearchConceptsGWAS summary statisticsGenome-wide association studiesComplex traitsSingle nucleotide polymorphismsGenetic covarianceGenetic architectureLarge-scale genome-wide association studiesStrong genetic covarianceDistinct genetic architecturesSignificant genetic covarianceLate-onset Alzheimer's diseaseHigh minor allele frequencyGenetic profileFunctional genomeAmyotrophic lateral sclerosisMajor neurodegenerative diseasesMinor allele frequencyGenetic basisAssociation studiesTraitsLarge-scale inferenceSummary statisticsBiological interpretabilityAllele frequenciesNeurodegenerative diseases